Prehospital Automatic Ventilation on Resuscitation Outcomes in Out-of-hospital Cardiac Arrest Patients: a Randomized Controlled Trial

National Taiwan University Hospital1 site in 1 country514 target enrollmentOctober 2, 2023

ConditionsOut-Of-Hospital Cardiac Arrest

Overview

Phase: Not Applicable
Intervention: Not specified
Conditions: Out-Of-Hospital Cardiac Arrest
Sponsor: National Taiwan University Hospital
Enrollment: 514
Locations: 1
Primary Endpoint: The percentage of any return of spontaneous circulation (ROSC)
Status: Recruiting
Last Updated: last year

Overview Investigators Eligibility Criteria Outcomes Sites Similar Trials

Overview

Brief Summary

The goal of this randomized controlled trial is to compare prehospital ventilation strategies in out-of-hospital cardiac arrest. The intervention group is automatic ventilation and the control group is manual ventilation. The main questions it aims to answer are:

How does automatic ventilation affect OHCA patients' survival and prognosis comparing to manual ventilation.
What are the differences on resuscitation qualities between automatic ventilation and manual ventilation.

Registry

clinicaltrials.gov

Start Date

October 2, 2023

End Date

September 30, 2026

Last Updated

last year

Study Type

Interventional

Study Design

Parallel

Sex

All

Investigators

Sponsor

National Taiwan University Hospital

Responsible Party

Sponsor

Eligibility Criteria

Inclusion Criteria

•Age over 18 years old at the time of occurrence of out-of-hospital cardiac arrest (OHCA).
•Attended by the Hsinchu County Fire Department for emergency medical assistance.

Exclusion Criteria

•Pregnant women.
•OHCA caused by trauma.
•Return of spontaneous circulation (ROSC) observed at the scene.
•Clearly deceased at the scene (reaching conditions such as decomposition, rigor mortis, severe burns, decapitation, evisceration, or trunk fracture).
•Refusal of medical transportation by family members.
•No placement of an advanced airway throughout the procedure.

Outcomes

Primary Outcomes

The percentage of any return of spontaneous circulation (ROSC)

Time Frame: 2 hours

The patient achieved ROSC in prehospital or inhospital resuscitation.

Secondary Outcomes

The percentage of sustained ROSC in 24 hours(up to 24 hours)
The percentage of epinephrine injection(up to 1 hour)
The satisfaction of emergency medical technician (EMT) during the dispatch(up to 5 hours)
The percentage of intravenous catheter placement(up to 1 hour)
The percentage of survival to hospital discharge(up to 90 days)
The percentage of favorable neurological outcome after discharge(up to 90 days)
Chest compression fraction(up to 1 hour)
The percentage of pneumothorax(up to 3 days)