A comparative study of oral gabapentin versus oral pregabalin in acute post-operative pain management in patients undergoing urological procedures under sub-arachnoid block.

After obtaining approval and clearance from the institutional ethics committee, the patients fulfilling the inclusion criteria will be enrolled for the study after obtaining informed consent.

Demographic details of the patients will be recorded as per the case record form.

After a thorough pre-operative evaluation, visual analogue score (VAS) is explained to the patient. On the day of surgery, two hours prior to the procedure, patients are pre-medicated with Tab. Pantoprazole 40mg. Patients are randomly allocated into two groups based on computer generated random number table. The patients are unaware as to which group they belong.

Group A receive T.  Pregabalin 150mg and Group B receive T. Gabapentin 600mg. After shifting the patient to operating room, sub-arachnoid block is given with Inj. Bupivacaine heavy (0.5%) at a dose of 0.3mg/kg body weight with maximum dose limited to 20mg and the level was assessed.After surgery, all the patients received IV Paracetamol 1 gram and are shifted to the recovery room. All patients are given Inj. Tramadol 50mg as rescue analgesia, once VAS exceeds 4. The patients are subsequently shifted to ward. Post-operatively VAS score is assessed at 0,2,4,6 and 12 hours after surgery. Total amount of analgesic administered is recorded. Any adverse events like giddiness, nausea, vomiting in the first 24 hours of post-operative period is noted.