Efficacy of Modified Constraint-induced Movement Therapy in Children With Brain Damage: Evidence of Kinematic Study
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 48
- 试验地点
- 2
- 主要终点
- Kinematic analysis
研究概览
简要总结
This research centers on the comparison of the immediate efficacy (right after therapy) and the maintained efficacy (3 months and 6 months) between "Modified Constraint-Induced Movement Therapy" (mCIMT) group and control group at different age.
详细描述
"Modified Constraint-Induced Movement Therapy" is one of the most recent treatments for children with Brain damage.
This well-designed and follow-up RCT study compared home-based CIT with a control intervention (traditional rehabilitation, TR) by combining kinematic analysis and clinical evaluation, which is possible to examine whether functional improvement is accompanied by a change in motor control. We hypothesized that home-based CIT would induce better motor control strategies (shorter RT, MT, lesser MUs, MGA, and PMGA, and larger peak velocity (PV)) for greater functional gains than TR. Furthermore, the beneficial effects would be maintained at 3 and 6 months of follow-up. Findings of this study allow clinicians to understand the underlying motor control changes for functional improvement after home-based CIT.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- Single (Outcomes Assessor)
入排标准
- 年龄范围
- 4 Years 至 15 Years（Child）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Development learned-nonuse
- •Age range 4y/o-15y/o
- •Wrist ext 10˚, MP j't ext 10˚ in affected U/E
- •Can fallow up the simple instruction
- •Modified Ashworth Scale ≦2
- •Pediatric Motor Activity Log ≦2.5 (average)
排除标准
- •Related muscle skeleton surgery
- •Selective dorsal rhizotomy
- •Botulinum toxin in 6 months
- •Visual perception impaired
- •Hearing perception impaired
- •Balance ability impaired (in constrained)
结局指标
主要结局
Kinematic analysis
时间窗: 4 weeks (post-treatment), 12 week, 24 week
Bruininks-Oseretsky Test of Motor Proficiency (BOTMP)
时间窗: 4 weeks (post-treatment), 12 week, 24 week
All children underwent a series of upper limb assessments, including kinematic analysis and functional measures (primary and secondary outcomes), before the start of the intervention (pretreatment). An occupational therapist blinded to group assignment was trained to administer these measures. All participants underwent these assessments at 4 weeks immediately after intervention (post-treatment), and at 12-week follow-up and 24-week follow-up.
Peabody Development Motor Scales, subtest fine motor (PDMS-Ⅱ)
时间窗: 4 weeks (post-treatment), 12 week, 24 week
次要结局
- Pediatric Motor Activity Log ( PMAL )(4 weeks (post-treatment), 12 week, 24 week)
- Pediatric Functional Independence Measure ( WeeFIM )(4 weeks (post-treatment), 12 week, 24 week)
- Cerebral palsy quality of life (CPQoL)(4 weeks (post-treatment), 12 week, 24 week)