Mobility Assessment in Multi-morbidity
- Conditions
- BronchiectasisPeripheral Vascular DiseaseAnxietyHeart FailureStrokeAtrial FibrillationChronic Kidney DiseasesCoronary Heart DiseaseDepressionAsthma
- Registration Number
- NCT06473168
- Lead Sponsor
- Northumbria University
- Brief Summary
Multimorbidity (the presence of two or more coexisting long-term conditions) is a significant challenge facing the NHS, especially given UK's ageing population and the association with high levels of illness burden and healthcare costs. Over 50% of adults \>65 years have multiple long-term conditions (MLTCs).
Our group has validated a broad range of algorithms applied to single wearable sensors that have the potential to capture walking-related mobility outcomes (such as walking cadence and walking speed) accurately and reliably during activities of daily living across five single long-term conditions. These algorithms, however, cannot be readily applied to people with MLTCs because the effect of multimorbidity on mobility is amplified compared to single long-term conditions secondary to a greater number of complications and sequelae. Accordingly, the aim of this study is to validate algorithms that would allow robust estimation of walking-related mobility outcomes during daily life activities in MLTCs.
To meet our objectives, the investigators will perform: i) laboratory-based technical validation of existing and newly developed algorithms for walking-related mobility outcome detection; ii) unsupervised real-life validation of selected algorithms; and iii) examination of how well the validated walking-related mobility outcomes reflect global and disease specific characteristics in older adults with multimorbidity. The investigators will adopt an integrated patient-centric approach where patients with MLTCs will be engaged early in the project to provide input of their perception and concerns regarding mobility limitation in daily life activities.
The investigators aim to recruit 55 older adults (\>65 years), men and women, with multiple long-term conditions with the following inclusion criteria: having two or more of the following conditions including osteoarthritis, rheumatoid arthritis, osteoporosis, type 2 diabetes, depression and/or anxiety, hypertension, coronary heart disease, heart failure, atrial fibrillation, chronic obstructive pulmonary disease, asthma, bronchiectasis, chronic kidney disease, cancer, or stroke within the last 5 years.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- NOT_YET_RECRUITING
- Sex
- All
- Target Recruitment
- 55
- Adults ≥65 years old
- Able and willing to provide informed consent
- Able to read and write in English
- To be mobile (including the use of walking aids)
- Two or more of the following long terms conditions: Arthritis, Asthma, Atrial fibrillation, Bronchiectasis, Cancer, Chronic kidney disease, Chronic obstructive pulmonary disease, Coronary heart disease, Anxiety, Depression, Diabetes mellitus, Heart failure, Hypertension, Osteoporosis, Parkinson's disease, Peripheral vascular disease, Stroke or transient ischaemic attack
- Unable to give consent for the study
- Severe mental health problems
- Active malignancy (on chemotherapy/radiotherapy/planned urgent surgery)
Study & Design
- Study Type
- OBSERVATIONAL
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Cadence 7-day real world assessment Walking cadence measured in the real world obtained from the Inertial Measurement Units placed on the lower back and the wrist measured in steps/minute.
Stride length 7-day real world assessment Stride length measured in the real world obtained from the Inertial Measurement Units placed on the lower back and the wrist measured in meters.
Walking speed 7-day real world assessment Walking speed measured in the real world obtained from the Inertial Measurement Units placed on the lower back and the wrist measured in m/s.
Stride duration 7-day real world assessment Stride duration measured in the real world obtained from the Inertial Measurement Units placed on the lower back and the wrist measured in sec.
- Secondary Outcome Measures
Name Time Method Daily steps 7-day real world assessment Measured in the real world obtained from the Inertial Measurement Unit placed on the lower back and the wrist expressed in steps/day.
Turning angle 7-day real world assessment Measured in the real world obtained from the Inertial Measurement Unit placed on the lower back and the wrist expressed in deg/s.
Sedentarism 7-day real world assessment Measured in the real world obtained from the Inertial Measurement Unit placed on the lower back and the wrist indicating time spent in different types of activities such as sitting down, lying, and walking expressed in minutes per day.