NCT02767960CompletedNot Applicable
Change of Serum Tenascin-C Concentration and the Relationship With Hs-CRP，cTnI and Prognosis in Patients With Acute Coronary Syndrome
The First Affiliated Hospital of Dalian Medical University1 site in 1 country183 target enrollmentStarted: May 2016Last updated:
Conditions
Trial Snapshot
- Phase
- Not Applicable
- Status
- Completed
- Sponsor
- Enrollment
- 183
- Locations
- 1
- Primary Endpoint
- Serum Tenascin-C concentration
Study Overview
Brief Summary
This study valuates the serum Tenascin-C concentration in patients with acute coronary syndrome.
Detailed Description
It is found that Tenascin-C plays an important role in ventricular remodeling, heart failure, aortic dissection, rheumatic heart disease and other cardiovascular diseases, which may be a new marker for the diagnosis and prognosis prediction of these diseases. However, there is few relevant studies about the Tenascin-C concentration in patients with acute coronary syndrome.This study valuates the serum Tenascin-C concentration in patients with acute coronary syndrome.
Study Design
- Study Type
- Observational
- Observational Model
- Case Control
- Time Perspective
- Prospective
Eligibility Criteria
- Ages
- 18 Years to 80 Years (Adult, Older Adult)
- Sex
- All
- Accepts Healthy Volunteers
- No
Inclusion Criteria
- •.diagnosed as acute coronary syndrome,including STEMI,non-STEMI,and UAP.
- •with left ventricular ejection fraction（LVEF）>=45%
- •written informed consents are obtained
- •admitted within 24 hours after chest pain attacked
Exclusion Criteria
- •complicated with rheumatic heart disease, coronary arteritis, hypertrophic cardiomyopathy or dilated cardiomyopathy
- •complicated with malignant tumor,the immune system diseases, blood system diseases, recently (within 2 weeks) taking glucocorticoid drugs, the use of immunosuppressive agents and cerebral infarction
- •with acute or chronic infection, surgery or trauma in the last month
- •secondary hypertension, severe liver dysfunction,severe renal insufficiency
- •with abnormal thyroid function or allergy to iodine agent
- •refusal to sign the informed consent
Outcomes
Primary Outcomes
Serum Tenascin-C concentration
Time Frame: 12 months
Serum Tenascin-C concentration in ng/ml
Secondary Outcomes
- Relationship between Tenascin-C and high sensitive C reaction protein (hs-CRP) concentration(12 months)
- Relationship between Tenascin-C and Troponin-I (Tn-I) concentration(12 months)
- MACEs during 12-month follow-up(12 months)
Investigators
Rchuang
Professor
The First Affiliated Hospital of Dalian Medical University
Study Sites (1)
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