Trauma-focused treatment for PTSD patients with a comorbid borderline personality disorder: a feasibility study of Prolonged Exposure (PE) in an intensive format.

Completed

Conditions: posttraumatic stress disorder (PTSD) and trauma
10002861

Registration Number: NL-OMON38775

Lead Sponsor: ProPersona (Nijmegen)

Brief Summary: Not available

Detailed Description: Not available

Recruitment & Eligibility

Status: Completed

Sex: Not specified

Target Recruitment: 0

Inclusion Criteria

General inclusion criteria of the study:
- Age between 18 and 65 years
- Current DSM-IV diagnosis of PTSD established with a structured diagnostic interview (CAPS-1), and a severity score of CAPS > 50.
- Current DSM-IV diagnosis of BPD established with a standardized, semi structured, diagnostic interview (SCID-II),
- Recent and/or imminent suicidal behavior or serious non-suicidal self-injury;Inclusion criteria to start Prolonged exposure
- Not at imminent risk of suicide
- No recent suicide attempts or serious non-suicidal self-injury
- PTSD is the highest priority target for the patient

Exclusion Criteria

- Psychosis or delusion disorders (current or in the past)
- Bipolar disorder
- Substance abuse or dependence, or alcohol abuse or dependence
- Mental retardation.
- Insufficient ability to speak and write Dutch

Study & Design

Study Type: Interventional

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>- PTSD symptoms measured by the Posttraumatic Stress Symptom Scale, Self Report<br /><br>- Safety measured by adverse events like suicidal attempts, non-suicidal<br /><br>self-injury (NSSI), and crisis service use.<br /><br>- For treatment compliance issues, cancelled treatment appointments will be<br /><br>recorded throughout the DBT and PE programs, as is dropout of treatment.<br /><br>- PTSD symptom severity is measured with a clinician rated instrument: the<br /><br>Clinician-Administered PTSD Scale (CAPS-1)<br /><br>- Subjective ratings of improvement will be assessed with the Global Severity<br /><br>index (GSI)</p><br>

Secondary Outcome Measures

Name	Time	Method
<p>- Severity of Borderline Personality Disorder will be assessed with the<br /><br>Borderline Personality Disorder Severity Index (BPDSI)<br /><br>- Depression will be measured with the Beck Depression Inventory-II (BDI-II)<br /><br>- Dissociation will be measured with the Dissociative Experiences Scale -<br /><br>revised version (DES-II)<br /><br>- Posttraumatic cognitions will be measured by the Dutch version of the<br /><br>Posttraumatic Cognitions Inventory (PTCI)</p><br>