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Clinical Trials/NCT06419920
NCT06419920
Recruiting
Not Applicable

Prosthetic Performance Enhancement Trial

University of Nevada, Las Vegas1 site in 1 country35 target enrollmentJune 26, 2025

Overview

Phase
Not Applicable
Intervention
Not specified
Conditions
Not specified
Sponsor
University of Nevada, Las Vegas
Enrollment
35
Locations
1
Primary Endpoint
Session adherence
Status
Recruiting
Last Updated
4 months ago

Overview

Brief Summary

The purpose of this research is to determine the feasibility of an uneven terrain walking program for lower limb prosthesis users. The training is designed to induce step-to-step variability during walking within a safe environment, with the aim of improving walking skill and confidence.

Detailed Description

Despite advances in the technology for artificial limbs (prostheses), falling and the fear of falling continue to be barriers to mobility for many lower limb prosthesis users after their initial rehabilitation. The loss of ability and confidence in pursuing everyday tasks negatively impacts quality of life, and ongoing physical and mental health. This study will test and improve a rehabilitation training intervention involving walking on uneven ground to improve walking skill and confidence in lower limb prosthesis users. Lower limb prosthesis users will be recruited. Participants will be allocated randomly to receive either intervention A: training on a flat surface, or intervention B: training on an uneven surface. Depending on their ability and confidence, participants will complete the walking practice either on a treadmill or on a mat with an identical surface pattern. The walking practice will take place three times per week for four weeks. As each participant improves their ability, training tasks will be made more difficult by limiting handrail use, by increasing walking speed, and, for intervention B, also by making the walking surface more uneven. The objectives of this pilot study are to evaluate adherence and refine the training protocols in preparation for a definitive trial that will inform rehabilitation practices.

Registry
clinicaltrials.gov
Start Date
June 26, 2025
End Date
November 1, 2026
Last Updated
4 months ago
Study Type
Interventional
Study Design
Parallel
Sex
All

Investigators

Responsible Party
Sponsor

Eligibility Criteria

Inclusion Criteria

  • lower limb amputation at ankle (Symes) level and above
  • age 18+ years
  • fitted with a walking prosthesis and use it regularly for home and/or community ambulation
  • good socket fit, assessed by a score of 8-10 on the socket fit comfort scale
  • able to walk for three minutes at a time with or without an assistive device

Exclusion Criteria

  • leg/foot ulcer or other conditions that cause pain during weight-bearing
  • poor skin integrity that could cause tissue breakdown by walking
  • cardiovascular, respiratory or other critical health conditions that preclude moderate physical activity
  • unilateral or bilateral upper limb absence or loss at the wrist and above that precludes use of handrails bilaterally, or would require asymmetrical adaptation to body posture for use.
  • pregnancy

Outcomes

Primary Outcomes

Session adherence

Time Frame: Through study completion, over 4 weeks

Percentage of planned sessions attended, per participant.

Secondary Outcomes

  • L-test time(Pre-intervention, within 5 days post intervention)
  • Activities-specific Balance Confidence Scale summary score(Pre-intervention, within 5 days post intervention)
  • Average daily activity(Pre-intervention, within 5 days post intervention)
  • Four Square Step Test time(Pre-intervention, within 5 days post intervention)
  • Single leg stand time(Pre-intervention, within 5 days post intervention)
  • Two-minute walk test distance(Pre-intervention, within 5 days post intervention)
  • Protocol acceptability(End of intervention week 4)
  • Recruitment feasibility - recruitment rate(From start of recruitment period, to 12 month time point.)
  • Recruitment feasibility - participating clinics(Through study completion, from start of recruitment period, to end of recruitment period or 30 month time point, whichever is sooner.)
  • Recruitment feasibility - sample characteristics(Through study completion, from start of recruitment period, to end of recruitment period or 30 month time point, whichever is sooner.)
  • Activity data evaluation(Throughout activity monitoring period, over 2 weeks)
  • Maximum relative variability of lateral trunk velocity during uneven terrain in comparison to overground walking(Through study completion, over 4 weeks)
  • Contour depth at maximum relative variability(Through study completion, over 4 weeks)
  • Maximum relative step width variability during uneven terrain in comparison to overground walking(Through study completion, over 4 weeks)
  • Prosthesis Users Survey of Mobility t-score(Pre-intervention, within 5 days post intervention)

Study Sites (1)

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