NCT06716047进行中（未招募）1 期
Effects of DL-endopeptidase Produced by Probiotics on Human Intestinal NOD2 Ligands and Related Functions
Zhujiang Hospital1 个研究点 分布在 1 个国家目标入组 30 人开始时间: 2024年12月5日最近更新:
适应症
干预措施
试验速览
- 阶段
- 1 期
- 状态
- 进行中（未招募）
- 发起方
- 入组人数
- 30
- 试验地点
- 1
- 主要终点
- safty
研究概览
简要总结
We have discovered a type of probiotic that can target activating intestinal NOD2, which is related to a series of human health issues.
详细描述
This trial requires the subjects to take probiotics for a certain period of time, and we will collect blood, stool and questionnaires for subsequent testing, efficacy evaluation and safety evaluation.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Other
- 盲法
- Single (Participant)
入排标准
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Tend to participate the trial
- •Willing to provide written informed consent
排除标准
- •Recent use of probiotics, antibiotics, laxatives, or gastrointestinal ulcer medications within the past month.
- •Gastrointestinal symptoms (e.g., constipation, abdominal pain, diarrhea, melena, hematochezia) in the past month.
- •Other conditions considered by researchers for exclusion
研究组 & 干预措施
placebo
Placebo Comparator
resistant dextrin
干预措施: Oral administration (Other)
probiotics
Experimental
lactobacillus
干预措施: Oral administration (Other)
结局指标
主要结局
safty
时间窗: up to 2 weeks
Adverse reaction by questionnaire survey
NOD2 activation level
时间窗: up to 2 weeks
the level of NOD2 activation by fecal in vitro experiments
次要结局
- Intestinal barrier(up to 2 weeks)
研究者
研究点 (1)
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