Effect of Intraoperative Nociception Control Based on Analgesia Nociception Index (ANI) Monitoring on Stress Response During Total Laparoscopic Hysterectomy
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Patients Undergoing Total Laparoscopic Hysterectomy
- Sponsor
- Yonsei University
- Enrollment
- 72
- Locations
- 1
- Primary Endpoint
- Serum catecholamine (norepinephrine, epinephrine) level at the end of surgery
- Status
- Completed
- Last Updated
- 4 years ago
Overview
Brief Summary
The "Analgesia Nociception Index" (ANI; MetroDoloris Medical Systems, Lille, France), derived from an electrocardiogram (ECG) trace, has been proposed as a noninvasive guide to analgesia. The ANI monitor calculates HR variation with respiration, a response mediated primarily by changes in the parasympathetic nervous system (PNS) stimulation to the sinoatrial node of the heart. The aim of this study is to determine the relation between ANI monitor values and serum catecholamine levels. We will compare the serum catecholamine (norepinephrine, epinephrine) levels of conventional nociception control group and ANI-monitor guided nociception control group at the end of surgery.
Investigators
Eligibility Criteria
Inclusion Criteria
- •patients undergoing total laparoscopic hysterectomy under general anesthesia (American society of anesthesiologists classification 1\~3)
Exclusion Criteria
- •endometriosis
- •AP diameter of uterus \> 12cm
- •cognitive disorder
- •arrhythmia, pacemaker
- •chronic opioid use
- •diseases affecting autoimmune system (immune disease, diabetic neuropathy)
- •use of medications affecting ANI monitor (antimuscarinics, alpha-agonist, beta blocker)
- •illiteracy, foreigner
Outcomes
Primary Outcomes
Serum catecholamine (norepinephrine, epinephrine) level at the end of surgery
Time Frame: at the end of surgery (skin closure)
Blood samples for serum catecholamine (norepinephrine, epinephrine) will be drawn at the end of surgery and 1 hour after the end of surgery..
Secondary Outcomes
- hormone level (cortisol, adrenocorticotropic hormone)(at the end of surgery (skin closure) and 1 hour after the end of surgery)
- plasma inflammatory markers (IL-6, IL-10, HMGB1)(at the end of surgery (skin closure) and 1 hour after the end of surgery)
- serum catecholamine (norepinephrine, epinephrine) level(1 hour after the surgery)