Microparticles Circulating Plasma Concentration in Atrial Fibrillation After Percutaneous Occluding of the Left Atrium
- Conditions
- Atrial Fibrillation
- Interventions
- Other: blood sampling
- Registration Number
- NCT03361202
- Lead Sponsor
- Institut Mutualiste Montsouris
- Brief Summary
The aim of the study is to compare levels of differnts types of microparticles circulating before and after percutaneous occluding of the left atrium by patients with atrial fibrillation and patients control.
Hypothesis is that prothesis implantation will decrease levels of microparticles circulating in blood circulation because of occluding of the left atrium .
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- UNKNOWN
- Sex
- All
- Target Recruitment
- 50
Inclusion Criteria
atrial fibrillation group:
- high embolic risk (CHADS-VASC2 score ≥4)
- formal and final contraindication to anticoagulant therapy
- no heart thrombus on ETO and TDM before percuraneous occluding
control group:
- suspicion of stable coronary artery disease, coronary angiography scheduled and double platelet aggregation (clopidogrel and aspirine)
Exclusion Criteria
for both groups
- congestive heart failure, severe aortic stenosis, EP or TVP early.
Study & Design
- Study Type
- OBSERVATIONAL
- Study Design
- Not specified
- Arm && Interventions
Group Intervention Description Atrial fibrillation group blood sampling blood sampling control group blood sampling blood sampling
- Primary Outcome Measures
Name Time Method levels of microparticles expressing phosphatidylserine in atrial fibrillation group 45 days after Percutaneous Occluding of the Left Atrium. blood samples analized by flow cytometry
- Secondary Outcome Measures
Name Time Method
Trial Locations
- Locations (1)
Institut Mutualiste Montsouris
🇫🇷Paris, France