Validation of a Single-Subject Treatment Outcome Predictor for Repetitive Transcranial Magnetic Stimulation (rTMS) to Improve Negative Symptoms in Schizophrenia - PREMISS

Klinikum der Universität München, Campus Großhadern0 个研究点目标入组 76 人开始时间: 2020年7月10日最近更新: 2024年8月19日

适应症

试验速览

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•Diagnostic criteria for schizophrenia spectrum and other psychotic disorders according to DSM-5 assessed by the MINI (Delusional disorder”, Brief psychotic disorder”, Schizophreniform disorder”, Schizophrenia”, Schizoaffective disorder”, Other specified schizophrenia spectrum and other psychotic disorder”, Unspecified schizophrenia spectrum and other psychotic disorder”); PANSS negative sum score >20 points, 1 of items N1–N7 =4; stable antipsychotic medication for a week before baseline; signed informed consent Einwilligung in die Teilnahme an der klinischen Studie”

•Patient who is not suitable for the study in the opinion of the investigator; involuntary stay in hospital at the time of recruitment; clinically relevant instable medical comorbidity or condition; insufficient cognitive abilities measured by verbal IQ < 85 assessed by the WST; moderate or severe substance use disorder according to the DSM-5 criteria; factors not compatible with the use of rTMS or MRI, e.g. cardiac pace makers or other metallic implants; history of epileptic seizures; insufficient German language ability; pregnancy (women of childbearing potential must have a negative pregnancy test)

发起方

Klinikum der Universität München, Campus Großhadern