Assessing the effects of autologous conditioned serum (orthokine) on pain intensity, clinical symptoms, quality of life and work productivity in patients with knee osteoarthritis
Not Applicable
Recruiting
- Conditions
- Knee osteoarthritis.Gonarthrosis [arthrosis of knee]M15, M16,
- Registration Number
- IRCT201707046934N3
- Lead Sponsor
- Vice Chancellor for research of Tabriz University of Medical Sciences
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Recruiting
- Sex
- All
- Target Recruitment
- 50
Inclusion Criteria
age 30-80, having knee osteoarthritis grade II-IV according to Kellgren-Lawrence, having moderate to severe knee pain in the past 4 weeks, being interested to participate in the study.
Exclusion criteria: history of knee surgery or arthroscopy in the last six months, history of trauma, history of knee injection during the past 3 months (steroids, hyaluronate, PRP, ACS, ACP), having rheumatoid arthritis or other systemic bone or joint diseases, active inflammation of patellofemoral, BMI>30 kg/m2, malignancy, infection, pregnancy
Exclusion Criteria
Not provided
Study & Design
- Study Type
- interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Pain intensity. Timepoint: baseline, weeks 3,6,12,24, 48 and after 2 and 3 year. Method of measurement: NRS.;Clinical symptoms (pain, stiffness, daily function). Timepoint: baseline, weeks 3,6,12,24, 48 and after 2 and 3 year. Method of measurement: WOMAC.;Quality of life. Timepoint: baseline, weeks 3,6,12,24, 48 and after 2 and 3 year. Method of measurement: SF-36.;Work Productivity and Activity Impairment. Timepoint: baseline, weeks 3,6,12,24, 48 and after 2 and 3 year. Method of measurement: WPAI.
- Secondary Outcome Measures
Name Time Method