A Clinical Profile of Parkinsons disease and association of disease duration with cognitive impairment.

Parkinson’s disease is one of the most common neurodegenerative diseases. Cognitive dysfunction and dementia are common in Parkinson’s disease, and the presence of dementia appears to be an independent predictor of mortality in PD. There is a distinct  Lack of studies on cognitive impairment in PD patients from India.  Along with the highly variable clinical course and progression of disease and dementia,  the underlying pathologic and anatomical basis of dementia in PD is also poorly understood.  Recognition of cognitive dysfunction early is important to improve therapeutic outcomes and prevent complications.  This trial aims to describe the epidemiological and clinical characteristics of patients with Parkinson’s disease presenting to a tertiary care hospital in India with a special focus on cognitive profile with special focus on comparing cognitive impairment in groups of Parkinson’s disease patients with duration of disease. This study will help in identifying patients at risk for developing cognitive impairment as well as identifying clinical markers associated with cognitive decline in patients with PD. This would be helpful as potential for new therapeutic options to delay or prevent cognitive impairment would be best in early phase or preclinical stage of disease.