Early Life Nutritional Exposures and Long-term Health and Cognitive Outcomes

Completed

• Conditions: Overnutrition; Undernutrition

• Registration Number: NCT01979770
• Lead Sponsor: Mahidol University

Brief Summary

This study aims to investigate the relationship of the various exposures during infancy and childhood on later health and development of adolescents. Various exposures to be assessed include, but not limit to, nutritional status, body composition, energy expenditure, dietary intake, micronutrient status, breastfeeding, lifestyle, and other environment exposures.

The study will specifically aim to respond these research questions:

1.1 What are the factors associated with overweight, obesity, and stunted in adolescents? 1.2 What are the factors associated with increased risk of NCDs during adolescence? 1.3 What are the factors associated with cognitive functioning during adolescence? Since numerous variables were collected, additional research questions can be possibly studied or other interested variables can be included in the future.

Detailed Description

A longitudinal data were collected in children in the northeast of Thailand beginning at 4-6 months of age and every 2 months through 10-12 months of age while children had been given iron and/or zinc supplementation. Biochemical, anthropometric, socio-demographic, feeding practices, and maternal characteristics data were collected. Children were followed up at 9 years of age to assess the long-term consequences of supplementation and early life nutrition on cognitive functioning and growth. There is a need to continue the follow-up of this study in order to address the association between early nutritional exposures and risks of cardio-metabolic dysfunction and cognitive and behavioral development later in childhood, adolescence and adulthood. Thus, we propose to follow-up these children during adolescence to assess the relationship of early life nutrition and exposures during infancy and childhood and outcomes including nutritional status, cognitive functioning, and risk for non-communicable diseases (NCDs). Findings from this study could provide awareness and information in developing policies and timely interventions to maintain optimal nutritional status throughout vulnerable life stages and reduce risks of NCDs and disabilities later in life.

Study Timeline

• Study Start: 2013-01-01
• Study First Submitted: 2013-07-28
• Study First Submitted QC: 2013-11-02
• Study First Posted: 2013-11-08
• Primary Completion: 2018-03-21
• Study Completion: 2018-03-21
• Status Verified: 2023-01
• Last Update Submitted: 2023-01-28
• Last Update Posted: 2023-01-31

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 529

Inclusion Criteria

• Apparently healthy children

Exclusion Criteria

• none

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Body composition	1 year	Body fat mass (kg), Body fat-free mass (kg) % body fat mass (%), % body fat-free mass (%)

Secondary Outcome Measures

Name	Time	Method
Cognition	1 year	IQ scores (IQ point)

Trial Locations

Locations (1)

Institute of Nutrition, Mahidol University; 🇹🇭 Salaya, Nakhon Pathom, Thailand