Corticostriatal Contributions to Parkinson's Disease Cognitive Impairment

Not Applicable

Recruiting

• Conditions: Parkinson Disease
• Interventions: Other: Neurophysiology recordings; Procedure: Neural stimulation

• Registration Number: NCT04715984
• Lead Sponsor: Vanderbilt University Medical Center

Brief Summary

The goal of this study is to learn more about the brain activity underlying Parkinson's disease cognitive impairment. The investigators will utilize neural recordings from corticostriatal structures performed during deep brain stimulation surgery to measure neural activity underlying nonmotor symptoms of Parkinson's disease.

Detailed Description

Not available

Study Timeline

• Study First Submitted: 2021-01-14
• Study First Submitted QC: 2021-01-14
• Study First Posted: 2021-01-20
• Study Start: 2021-06-02
• Status Verified: 2025-03
• Last Update Submitted: 2025-03-18
• Last Update Posted: 2025-03-21
• Primary Completion: 2026-02
• Study Completion: 2026-02

Recruitment & Eligibility

• Status: RECRUITING
• Sex: All
• Target Recruitment: 75

Inclusion Criteria

Not provided

Exclusion Criteria

Not provided

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: SINGLE_GROUP

Arm && Interventions

Group	Intervention	Description
Neural recordings and stimulation	Neurophysiology recordings	-
Neural recordings and stimulation	Neural stimulation	-

Primary Outcome Measures

Name	Time	Method
Changes in caudate DLPFC beta coherence	Baseline to end of Deep Brain Stimulation (DBS), approximately 3-4 hours	Caudate DLPFC coherence will be computed at rest and during the gambling task and correlated with cognitive metrics
Changes in gambling task performance with neural stimulation	Baseline to end of Deep Brain Stimulation (DBS), approximately 3-4 hours	The gambling task will involve seeing a series of cards presented on the screen and pressing a button to respond with a bet. Gambling task performance will be compared between stimulated and non stimulated blocks and between stimulation targets

Secondary Outcome Measures

Name	Time	Method
Change in beta power with neural stimulation	Baseline to end of deep brain stimulation (DBS) surgery, approximately 3-4 hours	Beta power will be computed and compared between stimulation on and off conditions for different targets

Trial Locations

Locations (1)

Vanderbilt University Medical Center; 🇺🇸 Nashville, Tennessee, United States