Corticostriatal Neurophysiology in Parkinson's Disease Cognitive Impairment
Overview
- Phase
- Not Applicable
- Intervention
- Neural stimulation
- Conditions
- Parkinson Disease
- Sponsor
- Vanderbilt University Medical Center
- Enrollment
- 75
- Locations
- 1
- Primary Endpoint
- Changes in caudate DLPFC beta coherence
- Status
- Recruiting
- Last Updated
- 2 months ago
Overview
Brief Summary
The goal of this study is to learn more about the brain activity underlying Parkinson's disease cognitive impairment. The investigators will utilize neural recordings from corticostriatal structures performed during deep brain stimulation surgery to measure neural activity underlying nonmotor symptoms of Parkinson's disease.
Investigators
Sarah Bick
Assistant Professor of Neurosurgery, Principal Investigator
Vanderbilt University Medical Center
Eligibility Criteria
Inclusion Criteria
- •Scheduled to undergo deep brain stimulation surgery under local anesthesia at Vanderbilt University Medical Center
- •Planned clinical electrode trajectory that contacts caudate
- •Age greater than or equal to 40
- •Diagnosis of Parkinson's disease
- •Able to participate in intraoperative testing
- •English speaking
Exclusion Criteria
- •Age less than 40
- •Not able to participate in intraoperative testing (for example unable to comprehend instructions or follow directions)
- •Movement disorder other than Parkinson's disease
Arms & Interventions
Neural recordings and stimulation
Intervention: Neural stimulation
Neural recordings and stimulation
Intervention: Neurophysiology recordings
Outcomes
Primary Outcomes
Changes in caudate DLPFC beta coherence
Time Frame: Baseline to end of Deep Brain Stimulation (DBS), approximately 3-4 hours
Caudate DLPFC coherence will be computed at rest and during the gambling task and correlated with cognitive metrics
Changes in gambling task performance with neural stimulation
Time Frame: Baseline to end of Deep Brain Stimulation (DBS), approximately 3-4 hours
The gambling task will involve seeing a series of cards presented on the screen and pressing a button to respond with a bet. Gambling task performance will be compared between stimulated and non stimulated blocks and between stimulation targets
Secondary Outcomes
- Change in beta power with neural stimulation(Baseline to end of deep brain stimulation (DBS) surgery, approximately 3-4 hours)