Corticostriatal Neurophysiology in Parkinson's Disease Cognitive Impairment
试验速览
- 阶段
- 不适用
- 状态
- 招募中
- 入组人数
- 75
- 试验地点
- 1
- 主要终点
- Changes in caudate DLPFC beta coherence
研究概览
简要总结
The goal of this study is to learn more about the brain activity underlying Parkinson's disease cognitive impairment. The investigators will utilize neural recordings from corticostriatal structures performed during deep brain stimulation surgery to measure neural activity underlying nonmotor symptoms of Parkinson's disease.
研究设计
- 研究类型
- Interventional
- 分配方式
- Na
- 干预模型
- Single Group
- 主要目的
- Basic Science
- 盲法
- None
入排标准
- 年龄范围
- 40 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Scheduled to undergo deep brain stimulation surgery under local anesthesia at Vanderbilt University Medical Center
- •Planned clinical electrode trajectory that contacts caudate
- •Age greater than or equal to 40
- •Diagnosis of Parkinson's disease
- •Able to participate in intraoperative testing
- •English speaking
排除标准
- •Age less than 40
- •Not able to participate in intraoperative testing (for example unable to comprehend instructions or follow directions)
- •Movement disorder other than Parkinson's disease
研究组 & 干预措施
Neural recordings and stimulation
干预措施: Neural stimulation (Other)
Neural recordings and stimulation
干预措施: Neurophysiology recordings (Other)
结局指标
主要结局
Changes in caudate DLPFC beta coherence
时间窗: Baseline to end of Deep Brain Stimulation (DBS), approximately 3-4 hours
Caudate DLPFC coherence will be computed at rest and during the gambling task and correlated with cognitive metrics
Changes in gambling task performance with neural stimulation
时间窗: Baseline to end of Deep Brain Stimulation (DBS), approximately 3-4 hours
The gambling task will involve seeing a series of cards presented on the screen and pressing a button to respond with a bet. Gambling task performance will be compared between stimulated and non stimulated blocks and between stimulation targets
次要结局
- Change in beta power with neural stimulation(Baseline to end of deep brain stimulation (DBS) surgery, approximately 3-4 hours)
研究者
Sarah Bick
Assistant Professor of Neurosurgery, Principal Investigator
Vanderbilt University Medical Center