Role of early hemodialysis on acute kidney injury in critically ill patients

Phase 2

Conditions: Acute renal injury.

Registration Number: IRCT201507069045N3

Lead Sponsor: Vice Chancellor for research , Tehran University of Medical Sciences

Brief Summary: Not available

Detailed Description: Not available

Recruitment & Eligibility

Status: Complete

Sex: All

Target Recruitment: 60

Inclusion Criteria

if there is one of the following scales such as ; at least 50% creatinine rise from the admission time ; BUN>70 ; oliguria <0.5 ml/kg/h for 12 hours with no response to volume and Furosemide ; anuria <0.3 ml/kg/h for 6 hours with no response to volume and Furosemide; will be specified as Early Hemodialysis Group (D) and if there is criteria such as volume overload ( pulmonary edema) ; BUN>100 or occurance of azotemia complications ( ex:loss of Consciousness ) and cr>4 will be specified as Group C. In case of oliguria (U/O<0.5 ml/kg/h) or aniria (U/O<0.3 ml/kg/h or cessation of urine ) , infusion of 500 ml crystalloid with 60 mg Furosemide in 1 hour will be administered and while there is no response , the patient entered the study; Exclusion criteria: history of renal insufficiency ; reception of high dose inotropics; septic shock ; severe electrolyte abnormalities leading to hemodialysis.

Exclusion Criteria

Not provided

Study & Design

Study Type: interventional

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Blood urea. Timepoint: Before intervention, daily after intervention. Method of measurement: Blood sample.;Plasma creatinine. Timepoint: Before intervention, daily after intervention. Method of measurement: Blood sample.;Urine volume. Timepoint: Before intervention, daily after intervention. Method of measurement: Fully catheter and urine bag.

Secondary Outcome Measures

Name	Time	Method
ength of stay in intensive care unit. Timepoint: Daily. Method of measurement: Number of admission days in intensive care unit.;Mortality rate in intensive care unit. Timepoint: Daily. Method of measurement: Rate of 28-day mortality.