Patterns of Disease, Outcomes and Treatment Response in Children With Neurodevelopmental Disorders
Overview
- Phase
- Not Applicable
- Intervention
- Cerebral Folate Deficiency
- Conditions
- Neurodevelopmental Disorders
- Sponsor
- Richard Frye
- Enrollment
- 1000
- Locations
- 1
- Primary Endpoint
- Number of Patients with Specific Medical abnormalities
- Status
- Recruiting
- Last Updated
- 16 days ago
Overview
Brief Summary
The purpose of this study is to systematically evaluate the results of medical investigations to identify symptom and biological patterns and common etiologies of neurodevelopmental disorders.
Detailed Description
Although neurodevelopmental disorders are very prevalent (for example Autism affects 1 out of every 36 children and dyslexia affects up to 15% of the population), the etiology of such disorders is not known. The purpose of this investigation is to identify common etiologies of neurodevelopmental disorders (i.e., speech delay, global developmental delay, autism) and determine if it is possible to find early indicators of the diagnosis and foster the potential for a better prognosis of these disorders. At this time the investigators examine patients with neurodevelopment disorders with various medical investigations, but the results of these investigations are not systematically evaluated. One of the goals of this research is to systematically examine this information in order to identify patterns of test abnormalities that have not been previously described. Another goal of this research is to identify the common etiologies typically identified by the medical evaluation, so we can further refine our approach. In addition, the investigators now have the ability to evaluate biological samples for biomarkers that have potential to be diagnostically useful.
Investigators
Richard Frye
Principal Investigator
Rossignol Medical Center
Eligibility Criteria
Inclusion Criteria
- •Neurodevelopmental delays Clinical visit at an Rossignol Medical Center
Exclusion Criteria
- Not provided
Arms & Interventions
Cerebral Folate Deficiency
Children with Cerebral Folate Deficiency will be followed in regards to their clinical management.
PANS
Children with PANS will be followed in regards to their clinical management.
PANDAS
Children with PANDAS will be followed in regards to their clinical management.
Epilepsy
Children with Epilepsy will be followed in regards to their clinical management.
ADHD
Children with ADHD will be followed in regards to their clinical management.
Autism
Children with autism will be followed in regards to their clinical management.
Mitochondrial Encephalopathy
Children with Mitochondrial Encephalopathy will be followed in regards to their clinical management.
Down Syndrome
Children with Down Syndrome will be followed in regards to their clinical management.
Dyslexia and other learning disabilities
Children with Dyslexia and other learning disabilities will be followed in regards to their clinical management.
Other Neurodevelopmental Disorders
Children with Other Neurodevelopmental Disorders will be followed in regards to their clinical management.
Outcomes
Primary Outcomes
Number of Patients with Specific Medical abnormalities
Time Frame: up to 7 years
It is unknown if a specific set of biological abnormalities contribute to the formation of many types of neurodevelopmental disorders. The study is intended to identify the relationship between biological abnormalities and neurodevelopmental disorders. The chart will be reviewed for medical diagnoses other than the primary neurodevelopmental disorders.
Secondary Outcomes
- The number of children with abnormal clinical lab(up to 7 years)
- The number of children who respond to specific treatments(up to 7 years)