OCT Angiography and NRAI in Dementia

Recruiting

• Conditions: Dementia; Mild Cognitive Impairment; Alzheimer Disease
• Interventions: Device: Optical Coherence Tomography Angiography (OCTA) Imaging; Device: Noninvasive Retinal Amyloid Imaging (NRAI)

• Registration Number: NCT03761381
• Lead Sponsor: Oregon Health and Science University

Brief Summary

The primary goals of this study are to use optical coherence tomography (OCT) angiography (blood vessel mapping) to:

1. Detect retinal blood vessel and blood flow changes in participants with dementia.

2. Detect amyloid protein deposits in the retinas of participants with dementia.

Detailed Description

Not available

Study Timeline

• Study First Submitted: 2018-07-02
• Study Start: 2018-09-14
• Study First Submitted QC: 2018-11-29
• Study First Posted: 2018-12-03
• Status Verified: 2024-02
• Last Update Submitted: 2024-02-08
• Last Update Posted: 2024-02-12
• Primary Completion: 2025-12
• Study Completion: 2025-12

Recruitment & Eligibility

• Status: RECRUITING
• Sex: All
• Target Recruitment: 20

Inclusion Criteria

Not provided

Exclusion Criteria

Not provided

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Arm && Interventions

Group	Intervention	Description
Dementia-Free Controls	Optical Coherence Tomography Angiography (OCTA) Imaging	This group will consist of adults without suspected dementia/Alzheimer's Disease. OCTA and NRAI data will be gathered in one study visit.
Dementia-Free Controls	Noninvasive Retinal Amyloid Imaging (NRAI)	This group will consist of adults without suspected dementia/Alzheimer's Disease. OCTA and NRAI data will be gathered in one study visit.
Early Dementia	Optical Coherence Tomography Angiography (OCTA) Imaging	This group will consist of adults with suspected dementia/Alzheimer's Disease. OCTA and NRAI data will be gathered in one study visit.
Early Dementia	Noninvasive Retinal Amyloid Imaging (NRAI)	This group will consist of adults with suspected dementia/Alzheimer's Disease. OCTA and NRAI data will be gathered in one study visit.

Primary Outcome Measures

Name	Time	Method
Retinal amyloid protein detection	1 day	OCT and OCT angiography will be used to detect levels of amyloid proteins deposits within the retina layers on the single enrollment visit only. An increase in the protein detection is expected in the dementia group.

Secondary Outcome Measures

Name	Time	Method
Decreased blood flow	1 day	OCT and OCT angiography will be used to detect blood flow in dementia vs dementia-free controls. OCT and OCTA imaging will be taken on the single enrollment visit only. Decreased blood flow is expected in the dementia group.
Decreased retinal perfusion	1 day	OCT and OCT angiography will be used to detect retinal perfusion deficits in dementia vs dementia-free controls. OCT and OCTA imaging will be taken on a single enrollment visit only. Decreased retinal perfusion is expected in the dementia group.

Trial Locations

Locations (1)

Oregon Health & Science University; 🇺🇸 Portland, Oregon, United States