Effects of Isoflavone Combined With Astaxanthin on Skin Aging

Not Applicable

Completed

• Conditions: Photo-aging; Ageing
• Interventions: Dietary Supplement: Isoflavone; Dietary Supplement: Placebo; Dietary Supplement: Astaxanthin

• Registration Number: NCT02373111
• Lead Sponsor: Seoul National University Hospital

Brief Summary

Photoaging is caused by the superposition of chronic ultraviolet (UV)-induced damage on the intrinsic aging process, and accounts for the majority of age-associated changes in skin appearance. Reactive oxygen species (ROS) play a key role in UV-induced skin damage and diminish skin matrix protein levels, leading skin aging. Strategies utilizing endogenous skin antioxidants as well as plant-derived or synthetic compounds have been examined.

Astaxanthin mainly from marine algae and crustaceans is a kind of carotenoids which were well-known photo-protective agents with strong antioxidant activity. Several studies have revealed that supplementation of astaxanthin effectively protect skin against UV damage through free radicals.

In addition, matrix metalloproteinase-1 induced by UV irradiation is an important step toward skin aging. Recently, many studies pointed out that phytoestrogens exhibit agonistic and antagonistic estrogen activities, suppressing activity of MMP-1 in skin. Isoflavone is a kind of phytoestrogen from soybean and mainly act on skin and bones, inhibiting MMP-1 effectively.

The present study is designed to take isoflavone combined with astaxanthin to maximize their anti-aging ability and objectively measure the effects of the mixture on facial wrinkles, hydration, and elasticity.

Detailed Description

Not available

Study Timeline

• Study First Submitted: 2015-02-20
• Study First Submitted QC: 2015-02-25
• Study First Posted: 2015-02-26
• Study Start: 2015-03
• Primary Completion: 2015-11
• Study Completion: 2015-12
• Status Verified: 2016-06
• Last Update Submitted: 2016-06-11
• Last Update Posted: 2016-06-14

Recruitment & Eligibility

• Status: COMPLETED
• Sex: Female
• Target Recruitment: 90

Inclusion Criteria

• Healthy females aged ≥ 45 years
• Facial wrinkle grade 2 to 4

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Exclusion Criteria

• received medical or cosmetic treatment that interferes with the general aging process at least 3 months before the study
• received any hormone replacement therapy at least 3 months before the study
• reported taking functional foods more than 1 month during last 3 months before the study
• history of acute or chronic disease such as severe liver or kidney disease
• history of allergies against any component of trial foods
• any visible skin disease that might be confused with a skin reaction to the test procedure

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Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
Isoflavone and Astaxanthin	Isoflavone	Each subject takes one active tablet per day for 24 weeks. Each tablet contains isoflavone 27mg and astaxanthin 4mg.
Placebo	Placebo	Each subject takes one placebo tablet per day for 24 weeks.
Isoflavone and Astaxanthin	Astaxanthin	Each subject takes one active tablet per day for 24 weeks. Each tablet contains isoflavone 27mg and astaxanthin 4mg.

Primary Outcome Measures

Name	Time	Method
Change from baseline in skin wrinkles	Twenty-four weeks	Facial wrinkles in the crow's feet area measured by Skin Visiometer

Secondary Outcome Measures

Name	Time	Method
Change from baseline in skin elasticity	Twenty-four weeks	Facial elasticity measured by Cutometer
Change from baseline in epidermal hydration	Twenty-four weeks	Skin hydration measured by Corneometer
Change from baseline in skin barrier integrity	Tewnty-four weeks	TEWL measured by Tewameter

Trial Locations

Locations (1)

Seoul National University Hospital; 🇰🇷 Seoul, Korea, Republic of