Effects of Isoflavone Combined With Astaxanthin on Skin Aging
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 90
- 试验地点
- 2
- 主要终点
- Change from baseline in skin wrinkles
研究概览
简要总结
Photoaging is caused by the superposition of chronic ultraviolet (UV)-induced damage on the intrinsic aging process, and accounts for the majority of age-associated changes in skin appearance. Reactive oxygen species (ROS) play a key role in UV-induced skin damage and diminish skin matrix protein levels, leading skin aging. Strategies utilizing endogenous skin antioxidants as well as plant-derived or synthetic compounds have been examined.
Astaxanthin mainly from marine algae and crustaceans is a kind of carotenoids which were well-known photo-protective agents with strong antioxidant activity. Several studies have revealed that supplementation of astaxanthin effectively protect skin against UV damage through free radicals.
In addition, matrix metalloproteinase-1 induced by UV irradiation is an important step toward skin aging. Recently, many studies pointed out that phytoestrogens exhibit agonistic and antagonistic estrogen activities, suppressing activity of MMP-1 in skin. Isoflavone is a kind of phytoestrogen from soybean and mainly act on skin and bones, inhibiting MMP-1 effectively.
The present study is designed to take isoflavone combined with astaxanthin to maximize their anti-aging ability and objectively measure the effects of the mixture on facial wrinkles, hydration, and elasticity.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- Double (Participant, Investigator)
入排标准
- 年龄范围
- 45 Years 至 —（Adult, Older Adult）
- 性别
- Female
- 接受健康志愿者
- 是
入选标准
- •Healthy females aged ≥ 45 years
- •Facial wrinkle grade 2 to 4
排除标准
- •received medical or cosmetic treatment that interferes with the general aging process at least 3 months before the study
- •received any hormone replacement therapy at least 3 months before the study
- •reported taking functional foods more than 1 month during last 3 months before the study
- •history of acute or chronic disease such as severe liver or kidney disease
- •history of allergies against any component of trial foods
- •any visible skin disease that might be confused with a skin reaction to the test procedure
结局指标
主要结局
Change from baseline in skin wrinkles
时间窗: Twenty-four weeks
Facial wrinkles in the crow's feet area measured by Skin Visiometer
次要结局
- Change from baseline in skin elasticity(Twenty-four weeks)
- Change from baseline in epidermal hydration(Twenty-four weeks)
- Change from baseline in skin barrier integrity(Tewnty-four weeks)
研究者
Jin Ho Chung
Professor
Seoul National University Hospital