Bisphosphonate Therapy for Osteogenesis Imperfecta

Phase 4

Completed

• Conditions: Osteogenesis Imperfecta; Osteoporosis; Paget Disease of Bone
• Interventions: Drug: Pamidronate; Drug: Alendronate

• Registration Number: NCT00159419
• Lead Sponsor: Indiana University School of Medicine

Brief Summary

The study is designed to evaluate the efficacy and safety of "Bisphosphonate Therapy for Osteogenesis Imperfecta (OI)." We, the researchers at Indiana University School of Medicine, are characterizing the changes effected by oral bisphosphonate therapy and comparing them to a regimen of intravenous bisphosphonate therapy in a group of children with OI and also in children with other disorders that result in low bone mass and fractures.

Detailed Description

The study is designed to evaluate the efficacy and safety of "Bisphosphonate Therapy for Osteogenesis Imperfecta (OI)." OI is an inherited disorder of collagen synthesis. Collagen is the major structural protein of the matrix of tendons, skin, and bones. Affected persons have low bone mineral density (and experience multiple fractures and progressive bony deformity). In its most severe form, the disorder is lethal in infancy. We plan to characterize the changes effected by oral bisphosphonate therapy and compare them to a regimen of intravenous bisphosphonate therapy in a group of children with OI.

Additionally, we have begun to treat patients with OI and other conditions of low bone mineralization for age who are not eligible for the standard protocol (too young, history of abdominal pain, etc.) with bisphosphonate. We also plan to screen the parents and siblings of our patients diagnosed with osteogenesis imperfecta, in order to determine if they also have osteoporosis.

Study Timeline

• Study Start: 1999-08
• Study First Submitted: 2005-09-07
• Study First Submitted QC: 2005-09-07
• Study First Posted: 2005-09-12
• Primary Completion: 2008-08
• Study Completion: 2008-08
• Results First Submitted: 2013-11-12
• Results First Submitted QC: 2016-02-29
• Results First Posted: 2016-03-31
• Status Verified: 2017-05
• Last Update Submitted: 2017-05-17
• Last Update Posted: 2017-06-14

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 18

Inclusion Criteria

• Diagnosis of OI, as defined by genetic analysis revealing a defect of type I collagen, OR by bone mineral density (BMD) <2.5 standard deviations (SD) for age plus two of the following:

  • Family history of OI
  • Frequent fractures
  • Blue sclerae
  • Multiple wormian bones on skull x-ray
  • Hearing disturbance
  • Dentinogenesis imperfecta

• Age between 3 and 21 years at the start of the study period.

• Children must be able to swallow whole tablets

• Parents of children must be able to understand protocol and give informed consent.

Exclusion Criteria

• Therapy with bisphosphonates during the past 12 months.
• Other "non-traditional" therapy for OI in the last 6 months, such as growth hormone or anabolic steroids.
• Other chronic diseases besides OI that interfere with bone morphology or gastrointestinal absorption

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
Pamidronate	Pamidronate	3 mg/kg IV q4 months
Alendronate	Alendronate	1 mg/kg po qd rounded to nearest 10 or 20 mg dose

Primary Outcome Measures

Name	Time	Method
Bone Mineral Density	2 years	By Dual-energy x-ray absorptiometry. Results were reported as z-scores as well as as absolute values. The Z-score indicates the number of standard deviations away from the mean. A Z-score of 0 is equal to the mean with negative numbers indicating values lower than the mean and positive values higher. Higher Z scores indicate a better outcome", or similar, as accurate and appropriate.