Quadruple Therapy Using Esomeprazole, Colloidal Bismuth Subcitrate, Amoxicillin-Clavulanate, and Furazolidone in Patients Who Failed to Eradicate H. Pylori With Triple Therapy
Overview
- Phase
- Not Applicable
- Intervention
- Augmentin (Amoxicillin-clavulanic)
- Conditions
- Treatment of Helicobacter Pylori
- Sponsor
- Aga Khan University
- Enrollment
- 176
- Locations
- 1
- Primary Endpoint
- Eradication of H. pylori infection resistant to triple therapy.
- Status
- Completed
- Last Updated
- 17 years ago
Overview
Brief Summary
Triple therapy, a combination of proton pump inhibitor with two antibiotics, is the gold standard for anti-Helicobacter pylori treatment. Usual antibiotics are clarithromycin, and either amoxicillin or one of the nitroimidazoles (metronidazole). However, there is an increasing evidence of H. pylori resistance to classical triple therapy. Another reason for this failure being low patient compliance with treatment. A regimen useful in one geographical area may not be effective or practical in another area. The aim of this study was to eradicate H. pylori infection resistant to triple therapy, establish the efficacy and safety of a 14-day therapeutic regimen to eradicate of H. pylori in patients who have failed with the classical triple therapy (omeprazole, clarithromycin and amoxicillin) given for 14 days.
Investigators
Eligibility Criteria
Inclusion Criteria
- •Informed consent given by the patient
- •Patients known to have H. pylori infection diagnosed by histopathology, rapid urease test and urea breath test
- •Failure to respond to classical triple regime of amoxicillin 1gram, clarithromycin 500mg and omeprazole 20mg twice a day for 10-14 days as documented by repeat urea breath test done one month after eradication therapy
Exclusion Criteria
- •Evidence of any malignancy, gastric outlet syndrome, history of gastric surgery, chronic liver disease, severe chronic renal failure, or any major co-morbidity.
- •known or suspected hypersensitivity to the medication used in the study
Arms & Interventions
Quadruple Therapy
Intervention: Augmentin (Amoxicillin-clavulanic)
Quadruple Therapy
Intervention: Furoxone (furazolidone)
Quadruple Therapy
Intervention: Cebes (colloidal bismuth subcitrate)
Quadruple Therapy
Intervention: Esso (esomeprazole)
Outcomes
Primary Outcomes
Eradication of H. pylori infection resistant to triple therapy.
Time Frame: 6 weeks
Secondary Outcomes
- Safety of the quadruple therapy(6 weeks)