The effect of obesity on dexmedetomidine dosing in ICU patients - retrospective study
Not Applicable
- Conditions
- ASA Physical state 1 to 3, 18 - 80 year old patients who underwent elective surgery and received intravenous dexmedetomidine in the IC
- Registration Number
- JPRN-UMIN000012466
- Lead Sponsor
- Fukushima Medical University
- Brief Summary
Fourteen obese patients and the same number of non-obese patients with similar backgrounds to the obese patients were selected from medical records. Doses of dexmedetomidine (DEX) in the first 48 h or until the end of sedation or extubation were calculated for comparison. There were no significant differences in DEX dose indices between the groups. However, DEX requirements (mcg/h) were significantly increased with TBW (kg) (r = 0.51, P = 0.003), BMI (r = 0.49, P = 0.006) and LBM (kg) (r = 0.42, P = 0.02).
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Complete: follow-up complete
- Sex
- All
- Target Recruitment
- 28
Inclusion Criteria
Not provided
Exclusion Criteria
History of neuropsychiatric disorder Taking psychiatric drugs Consciousness disturbance Underwent brain surgery Brain injury Underwent hepatectomy
Study & Design
- Study Type
- Observational
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method dexmedetomidine dosing
- Secondary Outcome Measures
Name Time Method