Quantification of Microbiota in Health and Diseases
- Conditions
- Disease
- Interventions
- Diagnostic Test: quantification of microbiota
- Registration Number
- NCT03388424
- Lead Sponsor
- University of Catanzaro
- Brief Summary
Microbiota consists of trillions of microorganisms located in all the biological cavity. The relationships between individual health status and microbiota are based on a sort of "mutual cooperation." The balance of the microbiota can be compromised by various factors such as environmental, psycho-physical stress, malnutrition (over or low), breastfeeding, chronic diseases, oncology and pharmacological treatments (especially antibiotics and chemotherapics). The impact of dysbiosis on today's society affects over 70% of the world population
- Detailed Description
Intestinal microbiota is defined as the strongest modulator of the human genome and it is considered the "second brain" of our organism for its bi-directional communication with the central nervous system. Microbiota consists of trillions of microorganisms located in all the biological cavity, In the intestine it is distributed in ecological niches having multiple metabolic activities which influence individual health. Microbiota acts as barrier against pathogens, regulating the absorption of nutrients, the production of energy and the development of the immune system4. Intestinal bacteria are generally divided into 4 Phylum: Firmicutes, Actinobacteria, Proteobacteria and Bacteriodetes, in which their proportion shows a correlation with individuals health status. When in equilibrium among them, these bacteria are essential for the good health of the digestive tract, the good function of immune system and for brain performace. The relationships between individual health status and microbiota are based on a sort of "mutual cooperation." The balance of the microbiota can be compromised by various factors such as environmental, psycho-physical stress, malnutrition (over or low), breastfeeding, chronic diseases, oncology and pharmacological treatments (especially antibiotics and chemotherapics). This disequilibrium leads to altered capability of bacteria to properly extract calories from food affecting the trend of many pathophisilogical status such as obesity, allergic states, inflammatory bowel syndromes cardiovascular diseases, metabolic, oncological and neurodegenerative diseases. The impact of dysbiosis on today's society affects over 70% of the world population
Recruitment & Eligibility
- Status
- UNKNOWN
- Sex
- All
- Target Recruitment
- 120
- all patients will be enclosed in each group in agreement with the characteristics of the groups
- Patients who will not sign the informed consent
Study & Design
- Study Type
- OBSERVATIONAL
- Study Design
- Not specified
- Arm && Interventions
Group Intervention Description quantification of microbiota in Brain quantification of microbiota Patients of both sex with neural disorders and diseases Control quantification of microbiota Healthy people of both sex quantification of microbiota in Lung quantification of microbiota Patients of both sex with Respiratory diseases quantification of microbiota in GI quantification of microbiota Patients of both sex with gastrointestinal diseases quantification of microbiota Metabolic quantification of microbiota Patients of both sex with Metabolic Diseases quantification of microbiota in UG quantification of microbiota Patients of both sex with Uro-genital Diseases
- Primary Outcome Measures
Name Time Method Determination of microbiota percentage 12 months we will determine the difference of microbiota percentage in diseases-groups respect to control-group
- Secondary Outcome Measures
Name Time Method Determination of antibiotic resistance gene 12 months it will be evaluate the presence of antibiotic resistance gene in diseases-group respect to control-group
Trial Locations
- Locations (1)
AO Materdomini
🇮🇹Catanzaro, Italia, Italy