Molecular evaluation of endometrium after endometrial injury

Phase 2

• Conditions: repeated implantation failure (RIF).; Female infertility, unspecified; N97.9

• Registration Number: IRCT20080831001141N28
• Lead Sponsor: ROYAN Institute

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Last Update Posted: 30 November 2020

Recruitment & Eligibility

• Status: Complete
• Sex: Female
• Target Recruitment: 20

Inclusion Criteria

Infertile women with repeated implantation failure (RIF) refers to cases in which women have had three failed in vitro fertilization (IVF) attempts with good quality embryos.

Exclusion Criteria

Women with Sub mucosal myoma
Women with Intramural and subserosal myomas larger than 5 cm
Women with Endometrioma larger than or equal to 3 cm
Women with Hydrosalpinx
If the number of available embryos is less than 2 in the current cycle
Women with endometrial tuberculosis and those undergoing tuberculosis treatment.
Patients with any specific medication
Patients with a history of thyroid disease, diabetes and other hormonal disorders and diseases
Failure to return the patient to prepare an endometrial sample
Inability to obtain tissue samples from patients due to severe pain or the possibility of infection

Study & Design

• Study Type: interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Evaluation of gene expression. Timepoint: In the endometrial sample obtained in the luteal phase during days 19-21 or 20-23. Method of measurement: Using PCR Array method and based on the copy number.

Secondary Outcome Measures

Name	Time	Method
Clinical pregnancy rate. Timepoint: Only once; 6 weeks after embryo transfer. Method of measurement: Vaginal ultrasound.