ITMCTR2024000027
Recruiting
未知
Clinical trial on the treatment of coronary microvascular disease with Shexiang Tongxin dropping pill
Guangdong provincial Hospital of Chinese Medicine0 sitesTBD
Conditionscoronary microvascular disease
Overview
- Phase
- 未知
- Intervention
- Not specified
- Conditions
- coronary microvascular disease
- Sponsor
- Guangdong provincial Hospital of Chinese Medicine
- Status
- Recruiting
- Last Updated
- 2 years ago
Overview
Brief Summary
No summary available.
Investigators
Eligibility Criteria
Inclusion Criteria
- •1\.Men or women aged 35\-75
- •2\.Symptoms of myocardial ischemia, including patients with stable angina pectoris and unstable angina pectoris
- •3\.LVEF \>50% or more confirmed by transthoracic cardiac ultrasound
- •4\.Perform coronary angiography or coronary CT (MSCT) to determine that there is no \>50% stenosis in the three major epicardial vessels, or prior PCI with no \>50% stenosis in the original stent
- •5\.Objective evidence of myocardial ischemia, such as ischemic changes on the electrocardiogram during angina episodes or ischemic changes on the electrocardiogram induced by the use of a flat\-plate exercise loading test, and/or abnormal ventricular wall motion
- •6\.Impaired coronary microvascular function is suggested by the use of any of the following tests:
- •a. Intracoronary pressure guidewire to detect the coefficient of microcirculatory resistance (IMR)
- •b. Selective coronary angiography suggests the phenomenon of slow coronary blood flow (TIMI flow frame count method)
- •c.Cardiac magnetic resonance imaging (CMR)
- •7\. Voluntarily undergo all examinations and follow\-up assessments required by the study protocol
Exclusion Criteria
- •1\. new acute myocardial infarction within 3 months
- •2\. Subjects cannot tolerate dual antiplatelet therapy
- •3\. Obvious hematopoietic system abnormalities, such as platelets \<72 x 10^9/L or \>700 x 10^9/L and white blood cells \<3 x 10^9/L
- •4\. Active bleeding and obvious bleeding tendency, such as active ulcers, recent ischemic stroke, history of hemorrhagic stroke, intracranial space\-occupying lesions, recent craniocerebral trauma, active bleeding from other organs that cannot be easily hemostatized, or bleeding tendency
- •5\. Combined with other organ failure, such as severe renal insufficiency (GFR\<30ml/min/1\.73m2\) or severe hepatic impairment (AST or ALT elevated more than 3 times the upper limit of normal value), combined with severe congestive heart failure (cardiac function\>class III). Suffering from serious diseases with a life expectancy of less than 12 months, such as malignant tumors, other diseases in advanced stages
- •6\. Pregnant women and women planning a pregnancy
- •7\. Acute infectious diseases
- •8\. Combined immune system diseases
- •9\. Subject is allergic to or has contraindications to concomitant medications required by the study protocol (e.g., aspirin, clopidogrel, statins, contrast agents, anticoagulants, nicorandil, muscimol drops, etc.)
- •10\. Patients with cognitive impairment, severe hearing and visual impairment who are unable to complete pre\-group communication and who refuse to be reviewed
Outcomes
Primary Outcomes
Not specified
Similar Trials
Completed
Phase 3
P030 clinical trialJPRN-jRCT2080224719IPRO CORPORATIO312
Not yet recruiting
Phase 2
A cohort study on the treatment of coronary heart disease with the method of promoting qi and blood circulation (retrospective)Coronary heart diseaseITMCTR2023000063Xiyuan Hospital, China Academy of Chinese Medical Sciences
Not yet recruiting
Not Applicable
A cohort study on the treatment of coronary heart disease with the method of promoting qi and blood circulation (prospective)Coronary heart diseaseITMCTR2023000064Xiyuan Hospital, China Academy of Chinese Medical Sciences
Completed
Phase 1
The TRIMAXX Coronary Stent TrialCoronary Artery DiseaseNCT00596661Abbott Medical Devices100
Recruiting
Phase 1
Clinical study for the treatment of atherosclerotic angiopathy with traditional Chinese MedicineatherosclerosisITMCTR1900002732Hebei Petro China Central Hospital