NCT04929002进行中（未招募）不适用
Using Carbon-13 Magnetic Resonance Spectroscopy to Assess Whether High Glycogen Levels in Skeletal Muscle of Patients With Glycogen Storage Diseases is a Prelude for Muscle Damage.
适应症
试验速览
- 阶段
- 不适用
- 状态
- 进行中（未招募）
- 入组人数
- 50
- 试验地点
- 1
- 主要终点
- Glycogen concentration
研究概览
简要总结
The project will use carbon-13 magnetic resonance spectroscopy to assess whether high glycogen levels in skeletal muscle of patients with Glycogen Storage Diseases is a prelude for muscle damage.
Patients with Glycogen Storage Diseases will be examined using carbon-13 MR-spectroscopy to quantify the glycogen levels in lumbar, thigh and calf-muscles. The pattern of glycogen concentration will be compared to the pattern of muscle atrophy found in the literature.
研究设计
- 研究类型
- Observational
- 观察模型
- Other
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Subjects with genetically verified neuromuscular disease or healthy control
- •Healthy controls needs to be healthy to be included, evaluated by the investigator
排除标准
- •Ferrous objects in or around the body
- •Pacemaker or other implanted electronic devices
- •Claustrophobia
- •Inability to understand the purpose of the trial or corporate for the conduction of the experiments.
- •Participation in other trials that may interfere with the results.
- •Competing conditions at risk of compromising the results of the study, evaluated by the investigator.
- •Strenuous exercise in the preceding 2 days before examination
- •Pregnancy or breastfeeding
结局指标
主要结局
Glycogen concentration
时间窗: Day 1
1. The difference in muscle glycogen between patients and controls 2. The difference in muscle glycogen between different muscle groups in patients.
次要结局
未报告次要终点
研究者
Mads Peter Godtfeldt Stemmerik
PhD-student, MD
Rigshospitalet, Denmark
研究点 (1)
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