Prospective observational clinical study to investigate the oral cavity microbiome in patients with depression treated with selective serotonin reuptake inhibitors (SSRIs)
Recruiting
- Conditions
- F33.8Other recurrent depressive disorders
- Registration Number
- DRKS00031660
- Lead Sponsor
- Mund-Kiefer- und Gesichtschirurgische Klinik, FAU Uniklinik Erlangen
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Recruiting
- Sex
- All
- Target Recruitment
- 68
Inclusion Criteria
Patients with or without SSRIs as permanent medication
Patients diagnosed with depression
Exclusion Criteria
- Patient is undergoing active periodontal treatment
- Increased tobacco consumption (>10 cigarettes per day)
- Patients with a disease that may affect the periodontium (e.g. diabetes mellitus, chronic inflammatory bowel disease)
- Poor general condition that does not allow dental diagnosis (retardation, dementia)
Study & Design
- Study Type
- observational
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Does an altered oral cavity microbiome show up in patients on SSRI medication
- Secondary Outcome Measures
Name Time Method Clinical parameters correlating with disease and PA<br><br>Probing depths PD (6 pages); Pardontal Screening Index PSI.<br> O: <3.5mm PD, no BOP, PI 0<br> 1: <3.5mm PD, BOP, PI 0<br> 2:<3.5mm PD, BOP, PI 1<br> 3: >3.5mm PD to 5.5mm<br> 4:>5.5mm<br>Bleeding on probing BOP<br>Suppuration<br>Recession<br>Percussion<br>Clinical attachment loss CAL<br>Degree of loosening<br>Plaque Index according to Mombelli (PI)<br> Grade 0: no plaque detectable by inspection and probing<br> Grade 1: accumulation of plaque visible only by probing in the sulcus with a probe but not by eye<br> Grade 2: visible plaque accumulation<br> Grade 3: massive plaque accumulation