Effects of Allium Hookeri on Blood Glucose

Not Applicable

Completed

• Conditions: PreDiabetes
• Interventions: Dietary Supplement: Placebo; Dietary Supplement: Allium hookeri extract

• Registration Number: NCT03330366
• Lead Sponsor: Chonbuk National University Hospital

Brief Summary

The researchers investigated the anti-diabetic effects of Allium hookeri root extract for Korean prediabetic participants.

Detailed Description

Allium hookeri root is widely consumed as a vegetable and herbal medicine in Asia. Although the antidiabetic activities of Allium hookeri have been documented in animal studies, the improved effects of Allium hookeri on human are not clear. Therefore, in this study, the researchers investigated whether Allium hookeri root extract could be effective in reducing the risk of type 2 diabetes in individuals with prediabetes.

Study Timeline

• Study Start: 2015-11-24
• Primary Completion: 2016-07-08
• Study First Submitted: 2017-10-30
• Study First Submitted QC: 2017-10-31
• Study First Posted: 2017-11-06
• Study Completion: 2018-03-31
• Status Verified: 2018-11
• Last Update Submitted: 2018-11-19
• Last Update Posted: 2018-11-20

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 30

Inclusion Criteria

• Fasting glucose 100~126 mg/dl

Exclusion Criteria

• Significant variation in weight (more 10%) in the past 3 months
• Treatment by hypoglycemic and hypolipidemic drug therapy within the past three months
• Type 1 diabetes or HbA1c>9.0%
• Cardiovascular disease
• Hypoglycemic agent, obesity medicine, and lipid lowering agent within past 6 months or blood sugar, obesity, and lipid improvement functional foods within past 2 monts
• Pregnancy or breast feeding

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: CROSSOVER

Arm && Interventions

Group	Intervention	Description
Placebo	Placebo	take two capsules per day for 8 weeks
Allium hookeri extract	Allium hookeri extract	take two capsules per day (486 mg/day) for 8 weeks

Primary Outcome Measures

Name	Time	Method
Changes of blood glucose during OGTT	8 weeks	Changes of fasting and postprandial glucose during OGTT were assessed before and after the intervention

Secondary Outcome Measures

Name	Time	Method
Changes of HbA1c	8 week	Changes of HbA1c were assessed before and after the intervention
Changes of C-peptide	8 week	Changes of C-peptide were assessed before and after the intervention
Changes of blood insulin	8 week	Changes of blood insulin were assessed before and after the intervention