A Phase 1a/1b Multiple Ascending Dose Study to Assess the Safety, Pharmacokinetics and Pharmacodynamics of SB 9200 in Treatment Naïve HCV Infected Adults
Overview
- Phase
- Phase 1
- Intervention
- SB9200
- Conditions
- Hepatitis C Infection
- Sponsor
- Syneos Health
- Enrollment
- 37
- Locations
- 4
- Primary Endpoint
- Safety
- Status
- Completed
- Last Updated
- 6 years ago
Overview
Brief Summary
The purpose of this study is to compare the safety and tolerability of ascending doses of SB 9200 given for up to 14 days to subjects with chronic Hepatitis C infection.
Detailed Description
This is a First-in-human, Two-stage, Multi-centre study. Part A is an open-label, single ascending dose study in fed or fasted subjects and Part B is a randomized, placebo-controlled multiple ascending dose study. The study is designed to evaluate the safety and tolerability of ascending doses of SB 9200 given as monotherapy for up to 14 days to subjects with chronic Hepatitis C infection, and to determine the pharmacokinetic and pharmacodynamic relationship over this dose range.
Investigators
Eligibility Criteria
Inclusion Criteria
- •Must provide written informed consent before any assessment is performed.
- •Must be willing and able to comply with scheduled visits, treatment plan, laboratory tests, and other study procedures.
- •Males or females of non-childbearing potential between the ages of 18 and 60 years, inclusive.
- •Must have HCV and laboratory evidence of HCV infection for at least six months before the Screening Visit.
- •Must have HCV-1 (1a or 1b or non-sub-typeable HCV-1), HCV-2 or HCV-3, as applicable for a given cohort.
- •Subjects must have a plasma HCV RNA \>5 log10 IU/mL (100,000 IU/mL).
- •Must have fibrosis of Stage 2 or lower by Ishak or Metavir scoring system or equivalent as evidenced by a recent (within two years of screening) liver biopsy (i.e. no more than moderate fibrosis). If a recent liver biopsy is not available, Fibroscan of \< 8.5 kilopascals at screening.
- •Must have negative human immunodeficiency virus (HIV) and Hepatitis B screening test results.
- •Must have a body mass index (BMI) of 18-32 kg/m2 (inclusive).
- •Must have screening laboratory values within the reference ranges or if outside the normal range, not clinically significant as judged by the Investigator. ALT and aspartate aminotransferase (AST) must be within 2x the upper limit of normal.
Exclusion Criteria
- •Any previous treatment with an investigational or approved drug or drug regimen for the treatment of HCV. Note: SB 9200 is excluded from this criterion, i.e. subjects who complete Part A of the study will be eligible to participate in Part B of the study.
- •History of hypersensitivity to any of the study drugs or to drugs of similar chemical classes.
- •Use of nonprescription drugs, vitamins and dietary supplements within 14 days or five half-lives (whichever is longer) prior to the trial dose medication. Changes to prescription medication within 14 days prior to the first dose of study medication (i.e. only stable prescription medications are permitted whilst on study).
- •History of intercurrent illness (e.g., upper respiratory illness with fever) within five days prior to the first dose of study drug.
- •History of illicit or controlled substance abuse or alcohol abuse within one year before the Screening Visit (with the exception of cannabinoids).
- •Any condition possibly affecting drug absorption (e.g., gastrectomy).
- •Long QT syndrome or QTc \> 450 msec for males and \> 470 msec for females at screening or baseline.
- •History of malignancy of any organ system (other than localized basal cell carcinoma of the skin), treated or untreated, within the past five years, regardless of whether there is evidence of local recurrence or metastases.
- •Women of child-bearing potential.
- •Fertile males, defined as all males physiologically capable of conceiving offspring unless the subject and partner of child bearing potential agree to comply with acceptable contraception and the female partner is not lactating.
Arms & Interventions
Experimental Part A
Experimental: Part A: Part A will use a single ascending dose protocol in small, open-label cohorts to determine the starting dose for Part B in the potentially therapeutic range. Intervention: SB9200
Intervention: SB9200
Experimental Part B
Experimental: Part B: Part B will use a multiple ascending dose protocol to further explore the safety, tolerability, pharmacokinetics and pharmacodynamics of SB9200 over 7-14 days of dosing. Intervention: SB9200 and Placebo
Intervention: SB9200
Experimental Part B
Experimental: Part B: Part B will use a multiple ascending dose protocol to further explore the safety, tolerability, pharmacokinetics and pharmacodynamics of SB9200 over 7-14 days of dosing. Intervention: SB9200 and Placebo
Intervention: Placebo
Outcomes
Primary Outcomes
Safety
Time Frame: Up to 35 days
Clinical safety data from 12-lead ECG, clinical laboratory tests, urinalysis, treatment-emergent adverse events, vital signs (blood pressure, heart rate, respiratory rate).
Secondary Outcomes
- Pharmacokinetic and Pharmacodynamic relationship of SB9200(Up to 35 days)
- Pharmacokinetic profile of SB9200(Up to 35 days)
- Effect of food on exposure of SB 9200(Up to 35 days)
- Short Term Antiviral Efficacy(Up to 35 days)
- Viral Resistance(Up to 35 days)
- IL28B Genotype(Up to 35 days)