The Effects of Intravascular Laser Irradiation of Blood on Reproductive Outcomes in Poor Ovaria n Responders Undergoing in Vitro Fertilization Cycles
试验速览
- 阶段
- 不适用
- 状态
- 进行中（未招募）
- 入组人数
- 60
- 试验地点
- 2
- 主要终点
- Ovarian reserve marker
研究概览
简要总结
The aim of this study was to investigate the effects of intravascular laser irradiation of blood on outcomes of in vitro fertilization cycles in poor ovarian responders.
详细描述
Intravascular laser irradiation of blood (ILIB) with He-Ne laser (632.8nm) has been applied on many organs and on the hematologic and immunologic system. Quite a number of both animal and human experiments have demonstrated that ILIB has a wide range of effects, including biostimulation, analgesia, antiallergic effects, immunomodulation, vasodilatation, antihypoxic, anti-oxidant, anti-aging and anti-inflammatory effects.
Poor ovarian responders (PORs) defined as poor or no response to ovarian stimulation had poor prognosis in assisted artificial technique (ART), which is a great challenge in in vitro fertilization (IVF) cycles. Previous studies showed that treatment with anti-oxidants could improve the outcomes of the poor ovarian responders; however, the effect is limited. Since ILIB has anti-aging, anti-oxidant and anti-inflammatory effects, the investigators hypothesize that ILIB may improve ovarian function and oocyte quality in PORs. Therefore, the investigators attempt to explore the effects of ILIB on the IVF outcomes in women with poor ovarian response.
研究设计
- 研究类型
- Interventional
- 分配方式
- Non Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- None
入排标准
- 年龄范围
- 30 Years 至 44 Years（Adult）
- 性别
- Female
- 接受健康志愿者
- 否
入选标准
- •Women who undergoes IVF cycles
- •BMI:18-30 kg/m2
- •Diminished ovarian reserve (AFC<5, AMH<1.2 ng/ml)
排除标准
- •Primary ovarian insufficiency
- •Congenital uterine anomaly
- •Severe intrauterine adhesion
- •Severe male factor (azoospermia)
- •Chromosome anomaly
- •Malignancy
- •Donor cycles
结局指标
主要结局
Ovarian reserve marker
时间窗: through study completion, an average of 1 year
Anti-mullerian hormone levels
Ongoing pregnancy rate
时间窗: through study completion, an average of 1 year
continuous presence of a fetal heartbeat over 12 weeks of a pregnancy
次要结局
- mitochondrial function of cumulus cells(through study completion, an average of 1 year)
研究者
Li-Te Lin
Principal Investigator
Kaohsiung Veterans General Hospital.