Efficacy of Low Dose Propofol Given at the End of Sevoflurane Anesthesia for Prevention of Emergence Agitation in Pediatric Patient Undergoing MRI Scan
试验速览
- 阶段
- 不适用
- 状态
- 尚未招募
- 入组人数
- 134
- 试验地点
- 1
- 主要终点
- incidence of emergence agitation
研究概览
简要总结
The goal of this clinical trial is to compare Efficacy of low dose propofol(0.5 mg/kg) vs placebo given at the end of sevoflurane anesthesia for prevention of emergence agitation in pediatric patient undergoing MRI scan. The main question it aims to answer is "Can low dose propofol reduce the incidence of emergence agitation after general anesthesia?" Participants will be given propofol 0.5 mg/kg or saline according to the allocated group at the completion of MRI scan
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Prevention
- 盲法
- Triple (Participant, Investigator, Outcomes Assessor)
入排标准
- 年龄范围
- 1 Year 至 8 Years（Child）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Age 2-8 years
- •ASA class I or II ,who schedule for MRI scan under sevoflurane anesthesia
排除标准
- •Developmental delay
- •Psychological and neurological disorders
- •Abnormal airway
- •Reactive airway disease
- •Allergy to propofol, egg product
- •Family history of malignant hyperthermia
- •Need iv sedative medication before induction
研究组 & 干预措施
group P
Receive 0.5 mg/kg of propofol intravenously at end of sevoflurane anesthesia
干预措施: Propofol (Drug)
group S
Receive saline intravenously at end of sevoflurane anesthesia
干预措施: Normal saline (Drug)
结局指标
主要结局
incidence of emergence agitation
时间窗: at 5,10,15,20,25,30 minutes after extubation
次要结局
- Incidence of complication(2 hours after extubation)
- Use of rescue medication(2 hours after extubation)
- Length of stay in post anesthetic care unit(2 hours after extubation)
- Emergence time(2 hours after extubation)
研究者
Santhita Pimonbut
Santhita Pimonbut
Khon Kaen University