Delayed Angioplasty Postconditioning in STEMI Patients
试验速览
- 阶段
- 2 期
- 状态
- 已完成
- 入组人数
- 72
- 试验地点
- 10
- 主要终点
- Size of the infarct
研究概览
简要总结
The investigators previously reported that angioplasty postconditioning reduces infarct size (cardiac enzyme release) in STEMI patients with a fully occluded coronary artery at hospital admission. Animal studies have suggested that the time window for applying brief episodes of ischemia and reperfusion aimed at triggering postconditioning's protection is very narrow, i.e. does not expand beyond 1 minute after reflow. We sought to address whether this window might be larger in humans, i.e. whether STEMI patients might be protected several minutes after undergoing spontaneous reperfusion before admission coronary angiography.
Therefore, STEMI patients (onset of chest pain less than 12 hours) with a TIMI flow grade > 1 were eligible for that study. Angioplasty postconditioning was completed as already published and infarct size was assessed by measuring cardiac enzymes release.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Patient > 18 years old
- •Male or female
- •Presenting first myocardial infarction, with the beginning of pains < 12 hours,
- •Requiring a revascularisation by primary angioplasty or " rescue " (after failure of thrombolysis) on LAD or RCA (not Circumflex coronary artery).
- •TIMI flow grade at admission of 2 or 3
- •LV angiography (RAO30°) before angioplasty.
排除标准
- •Cardiac arrest before the angioplasty
- •Cardiogenic shock
- •Occlusion of the artery circumflex responsible for the infarction
- •Visible collaterals to the area at risk
- •Magnetic resonance imaging: contra indication
结局指标
主要结局
Size of the infarct
时间窗: Day 5 post reperfusion
Size of the infarct estimated by magnetic resonance imaging at day 5 post-reperfusion
次要结局
- Contractile functional recovery(6 months after reperfusion)