A Comparison of Liver Function After Hepatectomy in Cirrhotic Patients Between Isoflurane Inhaled and Propofol Intravenous in Anesthesia with Epidural Block
- Conditions
- Hepatic carcinoma resection among cirrhotic patientsAnaesthesiology - AnaestheticsOral and Gastrointestinal - Other diseases of the mouth, teeth, oesophagus, digestive system including liver and colonCancer - Liver
- Registration Number
- ACTRN12610000063011
- Lead Sponsor
- Shanghai Rising-Star Program (No 08QA14007)
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Completed
- Sex
- All
- Target Recruitment
- 60
1. Elective liver resection
2. American Society of Anesthesiologists (ASA) physical status II-III patients
3. Primary liver cancer patients who had history of hepatitis B related cirrhosis
4. undergoing combined general and epidural anesthesia
1.Contradictions of epidural puncture including coagulate disorder (prothrombin time (PT) longer than 15 sec or/and blood platelets count less than 10,000)
2.Tumor size too large or small ( longitude of tumor was beyond 3-8 cm) or estimated blood loss was large than 1000 cc.
3.Individuals in whom the regional block failed and surgery was performed under general anesthesia alone were also withdrawn from the study.
4.Indivduals fail to be performed Pringer’s maneuver due to technologic problem.
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Postoperative liver fuctions and hepatocyte injury defined by peak alanine-aminotransferase (ALT) and aspartate-aminotransferase (AST) levels in blood analysis[On operation day,postoperative day 1,3,7]
- Secondary Outcome Measures
Name Time Method Serum Cytokine Tumor Necrosis Factor-a (TNFa) and Interleukin-1(IL1) levels[On operation day,postoperative day 1,3,7];Postoperative recovery: Hospital stay and Complications (eg. incidence rate (%) of hemorrhage,bile leak,wound infection,pleural effusion,hepatic decompensation,infective complications in each group, and postoperative complications were<br>assessed by treatment-oriented complication score.)[Entire Hospitalization]