Be-HealthY: Behavioral Risk Factors for Poor Vascular Health in Youth
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 41
- 试验地点
- 1
- 主要终点
- Arterial stiffness as assessed by Ambulatory Arterial Stiffness Index (AASI)
研究概览
简要总结
The investigators aim to determine the association of dietary intake on cardiovascular disease risk factors among children with overweight and obesity who are being evaluated for elevated blood pressure.
The investigators will also investigate for predictors of vascular function and determine if predictors vary by level of sodium intake.
详细描述
This research is being done to determine if the food or salt eaten can cause arteries to be stiffer and/or not work as well and if it can impact blood pressure over a 24-hour period of time. The investigators also want to determine if there are any risk factors or blood tests that can predict how stiff arteries are or how well arteries function. The investigators hope that the information from this study will help the investigators prevent blood pressure-related cardiovascular disease in children. This knowledge could help shape future guidelines on how to best prevent and treat high blood pressure and heart disease in children.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Cross Sectional
入排标准
- 年龄范围
- — 至 22 Years（Child, Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Overweight or obese
- •Elevated blood pressure
- •Referred to the ReNEW Clinic at Johns Hopkins University for evaluation and treatment of elevated blood pressure.
排除标准
- •The only children who will not be eligible for inclusion in this study are those who are non-English speaking.
结局指标
主要结局
Arterial stiffness as assessed by Ambulatory Arterial Stiffness Index (AASI)
时间窗: 1 day
The Ambulatory Arterial Stiffness Index will be determined from data obtained from vascular measures and during 24-hour ambulatory blood pressure monitoring. Arterial stiffness increases as the regression slope approaches 0 and the AASI approaches 1.
Endothelial function as assessed by Laser Doppler flow perfusion
时间窗: 1 day
The percent change in mean blood flow will be determined from Laser Doppler flow perfusion measurements obtained using a heating protocol.
Mean Blood pressure (mmHg)
时间窗: 1 day
Mean daytime systolic blood pressure in millimeters of mercury (mmHg) will be determined from 24-hour blood pressure monitoring.
Arterial stiffness as assessed by Pulse wave velocity
时间窗: 1 day
This will be determined from Pulse wave velocity (m/sec) done at the study visit
Arterial stiffness as assessed by Augmentation Index
时间窗: 1 day
The Augmentation Index (measured as a percentage) will be determined from a vascular assessment and data obtained during 24-hour ambulatory blood pressure monitoring. A greater Augmentation Index represents a stiffer, less compliant vessel.
次要结局
- Children's Emotion Management Scale (CEMS) score(1 day)
- Pediatric Adverse Childhood Events (ACEs) score(1 day)
- Behavior Assessment for Children (BASC) score(1 day)