Autologous Blood Transfusion After Local Infiltration Analgesia With Ropivacaine in Total Knee and Hip Arthroplasty
Overview
- Phase
- Not Applicable
- Intervention
- Autologous blood transfusion with ropivacaine
- Conditions
- Total Hip Arthroplasty
- Sponsor
- Northern Orthopaedic Division, Denmark
- Enrollment
- 52
- Locations
- 1
- Primary Endpoint
- Concentrations of ropivacaine in serum
- Status
- Completed
- Last Updated
- 11 years ago
Overview
Brief Summary
Total knee and hip arthroplasty for osteoarthritis is performed on still broader indications even in elderly patients with previous or current medical conditions. Especially comorbidity like cardiovascular diseases and conditions with increased risk of bleeding or previous thrombo-embolic events are major challenges.
To facilitate safe use of ropivacaine as an analgesic, information on the concentrations levels after autologous blood transfusion following local infiltration analgesia is very crucial. However, very limited data are available. To verify the safety of autologous blood transfusion, ropivacaine concentrations were studied in 52 patients undergoing either total knee arthroplasty or total hip arthroplasty.
Investigators
Eligibility Criteria
Inclusion Criteria
- •Clinical diagnosis for hip arthroplasty
- •Clinical diagnosis for knee arthroplasty
Exclusion Criteria
- •Patients \< 18 years
- •Lack of informed consent
- •Inability to read/understand Danish
- •Bilateral diagnosis
- •Cancer diagnosis
Arms & Interventions
Total knee arthroplasty
25 consecutive patients diagnosed for total knee arthroplasty.
Intervention: Autologous blood transfusion with ropivacaine
Total hip arthroplasty
27 patients diagnosed for total hip arthroplasty.
Intervention: Autologous blood transfusion with ropivacaine
Outcomes
Primary Outcomes
Concentrations of ropivacaine in serum
Time Frame: 6 hours
Concentrations of ropivacaine in serum before and after autologous blood transfusion will be analyzed.
Secondary Outcomes
- Analysis of ECG and pulse rate(6 hours)