Autologous Blood Transfusion After Local Infiltration Analgesia With Ropivacaine in Total Knee and Hip Arthroplasty
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 52
- 试验地点
- 1
- 主要终点
- Concentrations of ropivacaine in serum
研究概览
简要总结
Total knee and hip arthroplasty for osteoarthritis is performed on still broader indications even in elderly patients with previous or current medical conditions. Especially comorbidity like cardiovascular diseases and conditions with increased risk of bleeding or previous thrombo-embolic events are major challenges.
To facilitate safe use of ropivacaine as an analgesic, information on the concentrations levels after autologous blood transfusion following local infiltration analgesia is very crucial. However, very limited data are available. To verify the safety of autologous blood transfusion, ropivacaine concentrations were studied in 52 patients undergoing either total knee arthroplasty or total hip arthroplasty.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Retrospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Clinical diagnosis for hip arthroplasty
- •Clinical diagnosis for knee arthroplasty
排除标准
- •Patients < 18 years
- •Lack of informed consent
- •Inability to read/understand Danish
- •Bilateral diagnosis
- •Cancer diagnosis
研究组 & 干预措施
Total knee arthroplasty
25 consecutive patients diagnosed for total knee arthroplasty.
干预措施: Autologous blood transfusion with ropivacaine (Drug)
Total hip arthroplasty
27 patients diagnosed for total hip arthroplasty.
干预措施: Autologous blood transfusion with ropivacaine (Drug)
结局指标
主要结局
Concentrations of ropivacaine in serum
时间窗: 6 hours
Concentrations of ropivacaine in serum before and after autologous blood transfusion will be analyzed.
次要结局
- Analysis of ECG and pulse rate(6 hours)