NL-OMON47822已完成3 期
Prevention of severe GVHD after allogeneic hematopoietic stem cell transplantation, applied as consolidation immunotherapy in patients with hematological malignancies. A prospective randomized phase III trial. - HOVON 96 GVHD
HOVO0 个研究点目标入组 497 人开始时间: 待定最近更新:
适应症
试验速览
- 阶段
- 3 期
- 状态
- 已完成
- 发起方
- 入组人数
- 497
研究概览
简要总结
暂无简介。
研究设计
- 研究类型
- Interventional
入排标准
- 年龄范围
- 18 至 99（—）
入选标准
- •-Age 18-70 inclusive
- •-AML, MDS, ALL, MM, CML, CLL, NHL, HL, or a myeloproliferative disease (MPD)
- •-Planned allogeneic stem cell transplantation
- •-Related or unrelated donor with a 8/8 HLA match (HLA A, B, C, DRB1)
- •-WHO performance status 0-2
- •-Written Informed Consent
- •-Negative pregnancy test (if applicable)
- •-Patients who are willing and capable to use adequate contraception during
- •Myfortic treatment (all pre-menopausal women)
排除标准
- •- Renal dysfunction (serum creatinine > 150 mmol/L or clearance < 50 ml/min)
- •- Patients with active, uncontrolled infection
- •- Cord Blood transplantation
- •- Patients receiving ATG pre-transplantation as part of the conditioning regimen
- •- Patients with progressive disease in case of MM, CLL, NHL, HL
- •- Patients with > 5% marrow blasts in case of AML, ALL, CML
- •- Patients with EMD in case of AML, ALL, CML
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