ISRCTN57388990
Completed
Phase 2
Florbetapir F18 (18F-AV-45) amyloid PET imaging in focal dementia syndromes
Avid Radiopharmaceuticals Inc. (USA)0 sites25 target enrollmentNovember 8, 2011
Overview
- Phase
- Phase 2
- Intervention
- Not specified
- Conditions
- Focal dementia syndromes - primary aphasia
- Sponsor
- Avid Radiopharmaceuticals Inc. (USA)
- Enrollment
- 25
- Status
- Completed
- Last Updated
- 7 years ago
Overview
Brief Summary
No summary available.
Investigators
Eligibility Criteria
Inclusion Criteria
- •1\. Are currently enrolled in the longitudinal study of frontotemporal lobular degeneration at the Dementia Research Centre (DRC) at University College London (UCL)
- •2\. Patients with PPA will have undergone detailed neuropsychological assessments and will be classified in one of three syndromic groups: PNFA, LPA, or SD
- •3\. Can tolerate a PET scan procedure
- •PCA\-AD Group
- •1\. 1\.Are currently enrolled in the longitudinal study of posterior cortical atrophy at the Dementia Research Centre (DRC)
- •2\. Patients with PCA\-AD will have undergone detailed neurological assessments and will fulfil the following criteria:
- •2\.1\. Insidious onset of cognitive decline, sufficient to interfere with activities of daily living, with absence of structural lesion or significant whilte matter disease on magnetic resonnace imaging (MRI)
- •2\.2\. Relatively preserved episodic memory; deficits on standard psychological testing in at least two of four posterior cortical functions:
- •2\.2\.1\. Object perception
- •2\.2\.2\. Space perception
Exclusion Criteria
- •1\. Have clinically significant hepatic, renal, pulmonary, metabolic, or endocrine disturbances
- •2\. Have a clinically significant cardiovascular disease
- •3\. Have a clinically significant infectious disease
- •4\. Have a history of alcohol or substance abuse or dependence
- •5\. Have a history of severe drug allergy or hypersensitivity
- •6\. Women of child bearing potential
Outcomes
Primary Outcomes
Not specified
Similar Trials
Active, not recruiting
Phase 1
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Unknown
Phase 3
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