Natural Cycle or Stimulated Cycle Versus Hormone Replaced Cycle for Pre-eclampsia Rate

Not Applicable

• Conditions: Pre-Eclampsia

• Registration Number: NCT04310683
• Lead Sponsor: Women's Hospital School Of Medicine Zhejiang University

Brief Summary

Recent sutdies indicate that the existence of corpus lutein in the ovary is a key point to prevent preeclampsia, and patients undergoing FET with hormone replaced cycle have no corpus lutein and the absence of corpus lutein significantly increases the risk of preeclampsia in these patients. We aim to conduct a single center randomized trial study to compare the preeclampsia rate between the natural cycle and the hormone replaced cycle in patients undergoing FET.

Detailed Description

Not available

Study Timeline

• Status Verified: 2020-03
• Study First Submitted: 2020-03-14
• Study First Submitted QC: 2020-03-14
• Last Update Submitted: 2020-03-14
• Study First Posted: 2020-03-17
• Last Update Posted: 2020-03-17
• Study Start: 2020-11-10
• Primary Completion: 2021-12-10
• Study Completion: 2022-03-10

Recruitment & Eligibility

• Status: UNKNOWN
• Sex: Female
• Target Recruitment: 840

Inclusion Criteria

1. 18 to 42 years old women;
2. normal ovulation;
3. Scheduled to undergo frozen-thawed embryo transfer.
4. Agreeing with the informed consent.

Exclusion Criteria

1. Those who experienced embryo transfer cycle failure for at least three times;
2. One or both of the ovaries removed;
3. Hypertention disease before embryo transfer;
4. No available embryo for transfer
5. Oocyte or sperm donated cycles

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Primary Outcome Measures

Name	Time	Method
live birth rate	delivery	A delivery is considered successful live birth

Secondary Outcome Measures

Name	Time	Method
pre-eclampsia	From gestational week 20 to delivery	Preeclampsia is defined using the current American College of Obstetricians and Gynecologists definitions (Gynecologists; and Pregnancy 2013)