What is the effect of deep procedural sedation with HFNOT on tcPCO2, mitoPO2 and mitoVO2
Completed
- Conditions
- Patienten die diepe sedatie anesthesie ondergaan met HFNOTmonitored anesthetic caresedation
Recruitment & Eligibility
- Status
- Completed
- Sex
- Not specified
- Target Recruitment
- 35
Inclusion Criteria
- Age over 18 years
- Acceptable proficiency of the Dutch language
- Scheduled for a procedure requiring deep procedural sedation anesthesia with
HFNOT.
Exclusion Criteria
- Porphyria
- Known intolerance to components of the ALA plaster
- Presence of mitochondrial disease
- Pregnancy/lactation
- Patients with skin lesions on the measurement location which impede
measurements
- Incapability to provide inform consent, due to a mental condition interfering
with the ability to understand the provided information
Study & Design
- Study Type
- Observational non invasive
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method <p>- To examine the effects of HFNOT during deep procedural sedation on the tcPCO2<br /><br>- To determine the effects of HFNOT during deep procedural sedation on the<br /><br>mitoPO2 </p><br>
- Secondary Outcome Measures
Name Time Method <p>- To examine the effect of deep procedural sedation with HFNOT on the mitoVO2<br /><br>- To study the relationship between the tcPCO2 and the standard hemodynamic<br /><br>and respiratory parameters used during deep procedural sedation.<br /><br>o Non-invasive blood pressure<br /><br>o Peripheral Oxygen Saturation<br /><br>o Heart Rate<br /><br>o Respiratory Rate<br /><br>- To evaluate the relationship between the mitoPO2 and the standard hemodynamic<br /><br>and respiratory parameters used during deep procedural sedation.<br /><br>o Non-invasive blood pressure<br /><br>o Peripheral Oxygen Saturation<br /><br>o Heart Rate<br /><br>o Respiratory Rate</p><br>