Effect of Cherry Concentrate on Brain Activation and Perfusion in Healthy Older Adults
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 30
- 主要终点
- Brain perfusion
研究概览
简要总结
Effect of 8 weeks of cherry concentrate supplementation on cognitive function and brain perfusion in healthy older adults
详细描述
The investigators will perform a double blind, randomised controlled study to determine whether cherry polyphenols improve peripheral vascular function and cerebral perfusion resulting in improved task related brain activation and cognitive function. 30 healthy elderly men and women 60-85y years will be recruited to complete 8-week supplementation with MC concentrate or an isoenergetic cherry placebo concentrate. Participants will be pair matched for age, sex, and cognitive function (Adenbrooke's Cognitive Examination III, ACE-III) and then randomised using a sealed envelope system to receive either placebo or cherry.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Basic Science
- 盲法
- Triple (Participant, Investigator, Outcomes Assessor)
入排标准
- 年龄范围
- 60 Years 至 80 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •physically inactive consuming 5 or less portions of fruit per day Addenbrookes cognitive examination III score >88
排除标准
- •physically active consuming more than 5 portions of fruit per day Addenbrookes cognitive examination III score <88 Contraindications for MRI
研究组 & 干预措施
Cherry concentrate
8 weeks supplementation with montmorency cherry concentrate
干预措施: Cherry concentrate (Dietary Supplement)
Placebo concentrate
8 weeks supplementation with placebo isoenergetic cherry concentrate
干预措施: Placebo concentrate (Dietary Supplement)
结局指标
主要结局
Brain perfusion
时间窗: Change from baseline to 8 weeks supplementation
Arterial spin labelling using MRI, measure will be reported as ml/min
次要结局
- Brain activation (fMRI)(Change from baseline to 8 weeks supplementation)
- Plasma nitrite concentration(Change from baseline to 8 weeks supplementation)
- Cognitive function(Change from baseline to 8 weeks supplementation)