Clinical and Radiographic Evaluation of Zinc Incorporated Nano Hydroxyapatite Graft in Regeneration of Intrabony Defects- A Randomized Controlled Trial
试验速览
- 阶段
- 1 期
- 状态
- 进行中（未招募）
- 发起方
- 入组人数
- 12
- 试验地点
- 1
- 主要终点
- efficacy of Zinc Incorporated Nano hydroxyapatite graft regarding the following parameters as compared to Nano hydroxyapatite bone graft alone
研究概览
简要总结
Periodontitis is a disease of theperiodontium characterized by the irreversible loss of connective tissueattachment and supporting alveolar bone. 1
The ultimate goal of periodontaltherapy has been the regeneration of the new connective tissue attachment,i.e., new cementum with inserting collagen fibers, at diseased (denuded) rootsurfaces and also, the regrowth of alveolarbone. 2
Filling of the intrabony defects withvarious bone grafts is one of the most widely employed techniques aimed atrestoring the lost attachment. 3
Synthetic Hydroxyapatite (HA-Ca10(PO4)6(OH)2),due of its chemical similarity with natural bone mineral, is frequently used asbone grafting material.HA which isknown for its ability to bond with bone4, is not osteoinductive.Nevertheless, the crystal structure of HA can accommodate substitutions byvarious beneficial ions easily, amongst which zinc is a potential candidate.10
Zinc, has a stimulatory effect onbone formation and mineralization in vivo and vitro 5,6. Zinc acts toincrease bone formation and mineralization, decreases bone resorption,stimulates alkaline phosphatase (ALP) activity, in both calvaral organ culturesand osteoblast cell cultures. 5,7
Though Zinc-hydroxyapatite has beenshown to stimulate bone formation through the actions of zinc ions acceleratingthe proliferation and differentiation of osteogenic cells, no work has actuallybeen directed towards the use of ZnHA for potential applications in dentalfields. 8,10
Hence, the aim of this study will beto investigate the bone regenerative properties of a Zinc-nano hydroxyapatitegraft in comparison to nano-hydroxyapatite alone in the surgical management ofintrabony defects.
研究设计
- 研究类型
- Interventional
- 分配方式
- Computer generated randomization
- 盲法
- Participant and Investigator Blinded
入排标准
- 年龄范围
- 35.00 Year(s) 至 55.00 Year(s)（—）
- 性别
- All
入选标准
- •Systemically healthy patients, both males and females in the age range of 35-55 years having Chronic Generalized Periodontitis.
- •Patients with contralateral intra bony pockets measuring more or equal to 6 mm.
- •Patients with radiographic evidence of vertical/angular bone loss
- •Consenting patients who are co-operative and able to come for regular follow up
- •more than 20 remaining teeth.
排除标准
- •1.Pregnant /lactating women.
- •2.Patients allergic to zinc.
- •3.Patients on antibiotic therapy in the previous six months.
- •Patients who have undergone any periodontal therapy in past 6 months.
- •Patients who are medically compromised or under therapeutic regimen that may alter the probability of soft tissue and bone healing.
结局指标
主要结局
efficacy of Zinc Incorporated Nano hydroxyapatite graft regarding the following parameters as compared to Nano hydroxyapatite bone graft alone
时间窗: 12-month period, (3,6,9,12 month)
次要结局
- to evaluate Clinical parametersand Bone fill(3,6,9,12 months)