Risk Factors for Colonization and Infection With Antibiotic Resistant Bacteria Among Patients With Severe Intraabdominal Infections (IAI). An Open Observational Study

University Hospital, Linkoeping0 个研究点目标入组 200 人开始时间: 2006年2月最近更新: 2009年3月12日

适应症

试验速览

阶段: 不适用
发起方
入组人数: 200
主要终点: Primary End points for detection of AB-R Colonising index: (a) Proportion of patients colonised with AB-R strains per bacteria species.(b)Proportion of colonising cultures containing AB-R strains per bacteria species.

研究概览研究设计入排标准结局指标研究者记录与标识符相似试验

研究概览

简要总结

The objectives of the study were:

To study risk factors for colonization and infection with antibiotic resistant bacteria among patients with severe IAI before and after antibiotic treatment and surgical intervention.
To study species changes in the rectal flora among patients with severe IAI before and after antibiotic treatment and surgical intervention.
To review guidelines for antibiotic use in participating units.
To evaluate surgical antibiotic prophylaxis and treatment in relation to risk for colonization and infection with antibiotic resistant bacteria among patients with severe IAI
To use the results from the study in the process of a more appropriate use of antibiotics in participating units and care of patients with severe IAI.
To study the dynamics of extended-spectrum beta-lactamase producing and wild-type Enterobacteriaceae in patients with suspected severe intra abdominal infections before, during and after antibiotic treatment.

详细描述

In order to evaluate if standard empirical treatment was adequate in relation to resistance pattern among most prevalent species at admission we need another 70 patients to be included with at least data and cultures from admission.

研究设计

研究类型: Observational
观察模型: Case Only
时间视角: Prospective

入排标准

年龄范围: 18 Years 至 —（Adult, Older Adult）
性别: All
接受健康志愿者: 否

入选标准

•Patients with evidence of intra-abdominal infections that require surgical intervention will be eligible.
•In addition will patients with intra-abdominal abscess confirmed with CT/ultrasound be eligible, but not treated with surgical intervention if estimated to require at least 5 days antibiotic treatment, with a severity needing initial intravenous administration of antibiotics.

排除标准

•Age under 18 years

结局指标

主要结局

Primary End points for detection of AB-R Colonising index: (a) Proportion of patients colonised with AB-R strains per bacteria species.(b)Proportion of colonising cultures containing AB-R strains per bacteria species.

时间窗: 48 hours - 2 weeks after end of antibiotic treatment

次要结局

Proportion of patients with SSI other postoperative infections caused by AB-R strains, per infection type and per bacteria species.(48 hours - 2 weeks after end of antibiotic treatment)

研究者

发起方

University Hospital, Linkoeping

申办方类型

Other

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