KCT0007901
Not yet recruiting
未知
A Study of Treatment-free remission Evaluation in Real-world chronic myeloid leukemia-Prospective observational study
Overview
- Phase
- 未知
- Intervention
- Not specified
- Conditions
- Not specified
- Sponsor
- Gachon University Gil Medical Center
- Enrollment
- 200
- Status
- Not yet recruiting
- Last Updated
- 3 years ago
Overview
Brief Summary
No summary available.
Investigators
Eligibility Criteria
Inclusion Criteria
- •1\.\> 18\-year\-old male or female patient
- •2\. ECOG execution status 0, 1 or 2
- •3\. Patients diagnosed with BCR/ABL positive chronic\-phaseCML by bone marrow examination
- •4\. Patients receiving TKI treatment for at least three years after initial diagnosis, including imatinib, dasatinib, nilotinib, radotinib, etc.
- •5\. For qRT\-PCR follow\-up observation, patients with BCR/ABL1RQ\-PCR \< 0\.0069IS (MR4\.3 or higher) maintained for more than 2 years and had another confirmed response of 0\.0069IS or less at the central genetic testing institution that contracted for analysis.
- •6\. Patients who agreed to participate in the study
Exclusion Criteria
- •1\. Patients who had previously performed allografts
- •2\. Patients who tried to interrupt TKI before
- •3\. Past history of other active malignancies within 5 years prior to participation in clinical research, excluding fully cured or present basal cell skin cancer and past cervical endothelial cancer
- •4\. Patients who have not recovered from previous surgery
- •5\. Patients treated with other clinical research preparations within one to four weeks prior to the time of registration of the study
- •6\. Pregnant or lactating women
- •7\. Patients who may pose a risk to patient safety when determined by researchers
- •8\. Patients who attempted TKI interruption for reasons other than TFR
Outcomes
Primary Outcomes
Not specified
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