Proprioceptive Error Correction for Post-Stroke Upper Limb Rehabilitation

Not Applicable

Recruiting

• Conditions: Ischemic Stroke; Proprioception

• Registration Number: NCT07156955
• Lead Sponsor: Sungkyunkwan University

Brief Summary

The investigators aim to develop sensory transformation and augmentation technologies that minimize the impact of proprioceptive errors, thereby significantly enhancing motor learning and rehabilitation of the upper limbs. This study is designed to test proprioceptive error compensation techniques in stroke patients.

The human nervous system often receives mismatched information from vision and proprioception during upper limb control, resulting in conflicting sensory inputs that limit the effectiveness of motor learning. In other words, real-time sensory feedback - a critical component of motor learning in the nervous system - is not reliably delivered. Therefore, this study seeks to resolve sensory conflicts by providing additional sensory information through electrical stimulation, with the goal of dramatically improving the effectiveness of motor learning.

Detailed Description

Not available

Study Timeline

• Status Verified: 2025-08
• Study First Submitted: 2025-08-11
• Study First Submitted QC: 2025-08-27
• Last Update Submitted: 2025-08-27
• Study Start: 2025-09-01
• Study First Posted: 2025-09-05
• Last Update Posted: 2025-09-05
• Primary Completion: 2025-12-31
• Study Completion: 2026-08-30

Recruitment & Eligibility

• Status: RECRUITING
• Sex: All
• Target Recruitment: 3

Inclusion Criteria

• Diagnosed with ischemic or hemorrhagic stroke
• Stroke confirmed by CT or MRI
• Stroke patients with proprioceptive sensory deficits
• Chronic stroke patients with onset at least 3 months prior
• Able to voluntarily flex and extend the elbow joint
• Age 19 years or older
• Provide written informed consent (participant or legal representative)

Exclusion Criteria

• Severe pain during elbow joint movement
• Elbow joint contracture, spasticity, ataxia, musculoskeletal disorders, fractures, - non-healing ulcers, or open wounds
• Progressive or unstable stroke
• Presence of unilateral neglect
• Coexisting severe neurological disorders
• Major psychiatric disorders such as major depressive disorder, schizophrenia, bipolar disorder, or dementia Presence of a pacemaker

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: CROSSOVER

Primary Outcome Measures

Name	Time	Method
Improvement in upper limb motor function	6 visits over 3 weeks	Upper limb motor function will be evaluated using standardized clinical scales such as the Fugl-Meyer Assessment and proprioceptive accuracy tests.; 0 indicates severe movement limitation, while a score of 66 reflects normal motor function of upper limb.; Participants will undergo evaluations and treatment during six visits over approximately three weeks.

Secondary Outcome Measures

Name	Time	Method
Proprioceptive accuracy	Baseline before intervention and immediately after the 30-minute training session	Assessment of improvements in upper limb motor function and proprioceptive accuracy after applying sensory error correction techniques in stroke patients. Motor performance will be evaluated using standardized clinical scales and joint position sense tests. The expected outcome measures are a reduction of the error angle relative to the target angle to within ±5 degrees.

Trial Locations

Locations (1)

Shinchon Severance Rehabilitation Hospital; 🇰🇷 Seoul, South Korea