Assessment of liver function with Dynamic Contrast-Enhanced MRI in patients scheduled for liver resection - a pilot study.
- Conditions
- Liver cancerliver metastasis10019815
- Registration Number
- NL-OMON46928
- Lead Sponsor
- Academisch Medisch Centrum
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Completed
- Sex
- Not specified
- Target Recruitment
- 20
* Patients diagnosed with one or more liver lesions who are scheduled for 99mTc-HBS
* Visit 1 scheduled within preferably 7 but at most 14 days before or after 99mTc-HBS (with at least 4 hours between visits if scheduled on the same day)
* Age *18 years
* Signed informed consent obtained prior to any study-specific procedure
* General contraindications for MRI (such as pregnancy and claustrophobia)
* Chronic renal insufficiency or eGFR < 30 ml/min/1.73 m2
* Known or family history of congenital prolonged QT-syndrome
* Prior history of arrhythmia after the use of cardiac repolarisation time prolonging drugs
* Prior history of allergic reaction to gadolinium-containing compounds
* Prior history of asthma bronchiale
* Prior history allergic conditions
Study & Design
- Study Type
- Observational invasive
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method <p>* DCE-MRI: maximum enhancement, time to peak, slope of enhancement, wash-out<br /><br>rate<br /><br>* Quantitative T1 mapping: *T1<br /><br>* 99mTc-HBS (performed as part of clinical work-up): liver uptake function</p><br>
- Secondary Outcome Measures
Name Time Method <p>* Liver fat percentages (MR fat mapping)<br /><br>* Liver microperfusion (IVIM)<br /><br>* Histology results of the microscopic examination of the resected liver:<br /><br>* Degree of fibrosis and steatosis<br /><br>* Histology results of the microscopic examination of the liver biopsy of the<br /><br>future remnant liver:<br /><br>* Degree of fibrosis and steatosis</p><br>