P-CARRS-BRAIN: Multi-domain (genetic, socio-behavioral, vascular) risk factors and prediction of Alzheimer’s Disease continuum in South Asians in India (P-CARRS Brain Study).
试验速览
- 阶段
- 不适用
- 状态
- 尚未招募
- 发起方
- 入组人数
- 8,142
- 试验地点
- 3
- 主要终点
- In preliminary studies, it has successfully demonstrated the feasibility of administering novel AI-enabled digital cognitive assessment tools, collecting and processing plasma AD biomarkers, and pilot standardization of MRI neuroimaging biomarkers. This study will advance progress in understanding the natural history of the AD/ADRD along the life course and promote early detection, precise diagnosis and tailored therapeutic strategies for this high-risk, understudied population and beyond.
研究概览
简要总结
This study aims to enhance the understanding of Alzheimer’s Disease (AD) and the related diseases continuum (ADRD) starting in midlife. It seeks to identify novel risk factors and enable accurate disease prediction within the Precision CARRS cohort. The study will be conducted at two sites: CCDC (Delhi) and MDRF (Chennai), focusing on characterizing risks and outcomes in individuals who were enrolled in CARRS in two waves (2010, 2015) at ages ≥40 years.
研究设计
- 研究类型
- Observational
入排标准
- 年龄范围
- 40.00 Year(s) 至 99.00 Year(s)（—）
- 性别
- All
入选标准
- •Adults aged 40 years and more at baseline living in the urban areas of Delhi and Chennai.
排除标准
- •Pregnant women and bed-ridden individuals.
结局指标
主要结局
In preliminary studies, it has successfully demonstrated the feasibility of administering novel AI-enabled digital cognitive assessment tools, collecting and processing plasma AD biomarkers, and pilot standardization of MRI neuroimaging biomarkers. This study will advance progress in understanding the natural history of the AD/ADRD along the life course and promote early detection, precise diagnosis and tailored therapeutic strategies for this high-risk, understudied population and beyond.
时间窗: This study is a 5 year observational cohort study; so the outcome will be assessed after the completion of five years.
次要结局
未报告次要终点
研究者
Prof D Prabhakaran
Centre for Chronic Disease Control