Effects of Type II Collagen Association on Muscle Strength in Pain and Function of Patients with Knee Arthrosis

Not Applicable

• Conditions: Osteoarthritis; C05.550.114.606

• Registration Number: RBR-8ghcx3
• Lead Sponsor: niversidade Luterana do Brasil

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2019-07-08
• Last Update Posted: 29 May 2023

Recruitment & Eligibility

• Status: Recruitment completed
• Sex: Not specified
• Target Recruitment: Not specified

Inclusion Criteria

Men and women 40 to 75 years of age (this age group is justified because it covers the subjects with the stage of evolution of osteoarthritis of degree I to III); Unilateral and bilateral knee osteoarthritisfor more than three months with classification I to III in the radiological classification of Kelgren Lawrence confirmed by orthopedic doctor; Functional score of Lequesne higher than 4.5; Availability of dedication to treatment during the study period (six months); Patient agrees not to initiate any new physical or drug therapy for knee OA during the study period; Have signed the Term of Free and Informed Consent.

Exclusion Criteria

Grade IV knee osteoarthritis in the Kellgren-Lawrence radiological classification confirmed by orthopedist; Non-ambulatory; History of inflammatory arthropathy, septic arthritis, rheumatoid arthritis, inflammatory joint disease, uric acid gout, joint fracture, fibromyalgia, collagen genetic disease; Neurological diseases leading to cognitive deficits; History of asthma or type I or II diabetes; Psychiatric disorders; Symptomatic heart disease; Patients with clinical manifestations that do not allow the accomplishment of exercises; Presence of a skin or other type of skin disease at the level of the thigh; Urinary incontinence; Pregnancy; Alcoholism; Cancer; Patients with previous history of joint infiltration of corticoid or viscossuplementation in the knee in the last three months; History of trauma or knee surgery in the last six months; Three consecutive absences not justified physical rehabilitation.

Study & Design

• Study Type: Intervention
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Mean difference in pain level in the knee evaluated through the Visual Analog Pain Scale (VAS) from pre to post intervention, 90 days and 6 months after the intervention after the intervention, based on the observation of a variation of at least 5% in pre and post-intervention..

Secondary Outcome Measures

Name	Time	Method
Mean difference at the level of muscular strength in the knee evaluated by manual dynamometry from pre to post intervention, 90 days and six months after intervention, based on the observation of a variation of at least 5% in pre and post intervention measurements.