Safety and Efficacy Study of Transplantation of EPCs to Treat Idiopathic Pulmonary Arterial Hypertension

Zhejiang University1 个研究点分布在 1 个国家目标入组 40 人开始时间: 2006年6月1日最近更新: 2006年9月6日

适应症

试验速览

阶段: 不适用
发起方
入组人数: 40
试验地点: 1

研究概览研究设计入排标准研究者研究点记录与标识符相似试验

研究概览

简要总结

Experimental data suggest that transplantation of endothelial progenitor cells (EPCs) attenuates monocrotaline-induced pulmonary hypertension in rats and dogs. In addition, clinical studies suggest that autogolous progenitor cells transplantation is feasible and safe in patients with ischemic disease. This study will investigate the feasibility, safety, and initial clinical outcome of intravenous infusion of autologous EPCs in patients with idiopathic pulmonary arterial hypertension.

研究设计

研究类型: Interventional
分配方式: Randomized
干预模型: Parallel
主要目的: Treatment
盲法: Double

入排标准

年龄范围: 18 Years 至 60 Years（Adult）
性别: All
接受健康志愿者: 否

入选标准

•Clinical diagnosis of idiopathic pulmonary arterial hypertension
•in New York Heart Association (NYHA) functional class II to III
•a mean pulmonary artery pressure more than 30 mmHg on right heart catheterization
•the ability to walk ≥50 m during a standardized 6-minute walk test

排除标准

•Pulmonary hypertension as a result of heart disease, pulmonary disease, sleep-associated disorders, chronic thromboembolic disease, autoimmune or collagen vascular disease, HIV infection, liver disease, NYHA functional class IV, major bleeding requiring blood transfusion, diabetes, renal dysfunction, and evidence for malignant diseases were excluded

研究者

发起方

Zhejiang University

申办方类型

Other

研究点 (1)

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