Etude de l'Effet de Stimulations transcrâniennes en Courant Continu (tDCS) Sur Les Performances en dénomination Chez le Sujet Aphasique à Moins d'un an de Son Accident Vasculaire cérébral : Comparaison de 5 Configurations de Stimulation
Trial Snapshot
- Phase
- Not Applicable
- Status
- Terminated
- Sponsor
- Enrollment
- 5
- Locations
- 1
- Primary Endpoint
- Percentage of improvement of picture naming
Study Overview
Brief Summary
The aim of this work is to study the effect of transcranial direct current stimulation combined with naming therapy in acute and post-acute stroke comparing four bihemispheric positioning electrodes to a sham condition.
Detailed Description
TDCS have shown a positive effect on clinical outcome in naming treatment in aphasic subjects however some aspects as the positioning of the electrodes on the head are still unclear. That is why we compare the effects of four different positionings of the electrodes (two anterior over Broca's area and its homologue and two posterior over Wernicke's area and its homologue) to a sham stimulation in order to observe if a more important effect of one or another positioning could be found.
Study Design
- Study Type
- Interventional
- Allocation
- Randomized
- Intervention Model
- Single Group
- Primary Purpose
- Treatment
- Masking
- Double (Participant, Care Provider)
Eligibility Criteria
- Ages
- 18 Years to — (Adult, Older Adult)
- Sex
- All
- Accepts Healthy Volunteers
- No
Inclusion Criteria
- •man or woman of 18 years and older
- •aphasic patient following a first left hemispheric stroke
- •BDAE 3.0 aphasia score > or = to 1
- •stroke within 3 to 12 months before inclusion in the study
- •mother tongue = French
- •right handedness
- •signed informed consent
Exclusion Criteria
- •history of other neurologic pathologies
- •epileptic seizure within 2 months before inclusion
- •bilingual patient (2 mother tongues)
- •history of cranial surgery
- •presence of intracerebral metallic material
- •unauthorized molecules at inclusion : sulpiride, rivastigmine, dextromethorphan, carbamazepine, flunarizine, levodopa
- •pregnant, parturient or lactating woman
Arms & Interventions
F7A
Anodal electrode set on the left Broca's area and cathodal electrode set on its right homologue. Active stimulation.
Intervention: eldith DC-stimulator, configuration F7A (Device)
F7C
Cathodal electrode set on the left Broca's area and anodal electrode set on its right homologue. Active stimulation.
Intervention: eldith DC-stimulator, configuration F7C (Device)
T5A
Anodal electrode set on the left Wernicke's area and cathodal electrode set on its right homologue. Active stimulation.
Intervention: eldith DC-stimulator, configuration T5A (Device)
T5C
Cathodal electrode set on the left Wernicke's area and anodal electrode set on its right homologue. Active stimulation.
Intervention: eldith DC-stimulator, configuration T5C (Device)
Sham
Electrodes set on the left Broca's area and its right homologue or electrodes set on the left Wernicke's area and its right homologue, but no stimulation will be delivered.
Intervention: eldith DC-stimulator, configuration Sham (Device)
Outcomes
Primary Outcomes
Percentage of improvement of picture naming
Time Frame: Before stimulation and immediately after stimulation
Secondary Outcomes
No secondary outcomes reported